DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and Gpr165

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001100052.1	Gene:	Gpr165 / 296866	RGDID:	1564566	Length:	462	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	85/308 - (27%)
Similarity:	156/308 - (50%)	Gaps:	20/308 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DYDLLSED----MWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIG 150
            |.:::|:|    .|....:.|:|:.        |:|||..:.:|:....|:.|.|..|:.::::.
  Rat    91 DLEIVSQDEQVQFWLVVGYTIVVFA--------AIIGNWVLNHIIMKYKRVHTATGLFVVNISVT 147

  Fly   151 DILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPR 215
            :::::....|.:.:. ::.|...||...||...::|.....|:..::.|||:||:..:::|||.|
  Rat   148 NMMLALLSSPFTMVR-YLCNSLVFGKMTCHLSRFAQYSCAYVTVMSMAAISLDRHRVMLYPLKAR 211

  Fly   216 ITKRYATFIIAGVWFIALATALPIPIVSGLDIPMSPWHTKCEKYICREMWP--SRTQEYYYTLSL 278
            ||.......|..:|.::...|||..:...|  ....:....|:..|...:|  |::...|..|..
  Rat   212 ITPMQGNVCIIIIWIVSTCAALPHAVYQKL--YQVEFGNTTEESACLPSFPYTSKSTWKYLDLGT 274

  Fly   279 FALQFVVPLGVLIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPF 343
            |.|.|::||.||:..|..:..::|......:...:........|::.:||::|||:::|..|||.
  Rat   275 FLLFFILPLLVLVAVYGHVAKKLWIHDAVDDINIHTYICQRGKKKQTLKMLMTVVLLYTISWLPL 339

  Fly   344 NILQLLLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFR 391
            |:..:||:.|..:..:.|   :|..||||:|..||||.|||:::..||
  Rat   340 NLYLVLLSSESISSHNGL---YFFLHWLAISSSCYNPYIYCWLSDSFR 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	30/120 (25%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	72/262 (27%)
Gpr165	NP_001100052.1	7tmA_GPR83	103..387	CDD:320511	82/296 (28%)
		TM helix 1	105..129	CDD:320511	7/31 (23%)
		TM helix 2	138..160	CDD:320511	2/21 (10%)
		TM helix 3	176..198	CDD:320511	5/21 (24%)
		TM helix 4	219..235	CDD:320511	4/15 (27%)
		TM helix 5	268..291	CDD:320511	9/22 (41%)
		TM helix 6	322..344	CDD:320511	10/21 (48%)
		TM helix 7	355..380	CDD:320511	14/27 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910