Protein Alignment RYa-R and Hcrtr2

DIOPT Version :10

• Sequence 1: NP_001287552.1
• Gene: RYa-R / 43253
• FlyBaseID: FBgn0004842
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_037206.1
• Gene: Hcrtr2 / 25605
• RGDID: 2788
• Length: 460
• Species: Rattus norvegicus
• Alignment Length: 458
• Identity: 127/458 - (27%)
• Similarity: 200/458 - (43%)
• Gaps: 96/458 - (20%)

  Fly    56 DDEGSNYGYGSTTTLSGLQFETYNITVMMNFSCDDYD-------LLSEDMWSSAYFKIIVYMLYI 113
            :|......:.|.:.|:..|....|.|        |||       |..|.:....|..::: ..||
  Rat     7 EDSLPRRNWSSASELNETQEPFLNPT--------DYDDEEFLRYLWREYLHPKEYEWVLI-AGYI 62

  Fly   114 PIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILNYWPFGLAL 178
            .:|:.|||||..||..|:....|||||||||.:|::.|:|::..|:|::.: :.|...|.||.:|
  Rat    63 IVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLV-VDITETWFFGQSL 126

  Fly   179 CHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVWFIALATALPIPIVS 243
            |..:.|.|.|||.||..||..|::||:.||..||..:.|.:.|...|..:|.::....:|..||.
  Rat   127 CKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVM 191

  Fly   244 GLDIPMSPWHTKCEKY-ICREMWPSRTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPP 307
            .....:.....|...: :|.|.|........|.:..|.:.::.||.:::..|.:|..::|.::.|
  Rat   192 ERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIP 256

  Fly   308 GEAETNR----------------------------DQRMARSKRKMVKMMLTVVIVFTCCWLPFN 344
            |.:...:                            :.:..|::||..:|::.|::||..|:||.:
  Rat   257 GTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPIS 321

  Fly   345 ILQLL---------LNDEEFAHWDPLPYVWFAF-HWLAMSHCCYNPIIYCYMNARFRSGFVQLMH 399
            ||.:|         ..|.|..      |.||.| |||..::...|||||.:::.:||..|.....
  Rat   322 ILNVLKRVFGMFTHTEDRETV------YAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFS 380

  Fly   400 RMPGLRRWCCL---RSVGDRM--NATSGE----MTTKYHRHVGDALFRKPKICIRNGSSTSSQSN 455
                    |||   |..|||:  ..||.|    :||:                |.|..:.|..|
  Rat   381 --------CCLGVHRRQGDRLARGRTSTESRKSLTTQ----------------ISNFDNVSKLS- 420

  Fly   456 EHI 458
            ||:
  Rat   421 EHV 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tmA_PR4-like	106..394	CDD:320514	96/326 (29%)
		TM helix 1	107..133	CDD:320514	11/25 (44%)
		TM helix 2	140..165	CDD:320514	10/24 (42%)
		TM helix 3	179..209	CDD:320514	14/29 (48%)
		TM helix 4	220..241	CDD:320514	4/20 (20%)
		TM helix 5	271..300	CDD:320514	6/28 (21%)
		TM helix 6	320..350	CDD:320514	13/38 (34%)
		TM helix 7	362..387	CDD:320514	12/25 (48%)
Hcrtr2	NP_037206.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49		5/15 (33%)
		7tmA_OXR	55..375	CDD:320336	96/327 (29%)
		TM helix 1	56..82	CDD:320336	11/26 (42%)
		TM helix 2	89..115	CDD:320336	10/26 (38%)
		TM helix 3	127..157	CDD:320336	14/29 (48%)
		TM helix 4	168..189	CDD:320336	4/20 (20%)
		TM helix 5	220..249	CDD:320336	6/28 (21%)
		TM helix 6	297..327	CDD:320336	12/29 (41%)
		TM helix 7	343..368	CDD:320336	12/24 (50%)
		Orexin_rec2	386..443	CDD:427531	15/55 (27%)