DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and Hcrtr1

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_037196.1	Gene:	Hcrtr1 / 25593	RGDID:	2787	Length:	416	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	116/415 - (27%)
Similarity:	185/415 - (44%)	Gaps:	80/415 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DYD-----LLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAI 149
            ||:     .|..|......::.::...|:.:|:.||:||..||..|:....|||||||||.:|::
  Rat    26 DYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSL 90

  Fly   150 GDILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKP 214
            .|:|::..|:|:|.: :.|...|.||.|||..:.|.|||||.|:..||..|::||:.||..||..
  Rat    91 ADVLVTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF 154

  Fly   215 RITKRYATFIIAGVWFIALATALPIPIVSGLDIPMSPWHTKCEKY-ICREMWPSRTQEYYYTLSL 278
            :.|.|.|...|.|:|.::||..:|...|......:.....:...: :|.|.|........|....
  Rat   155 KSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCF 219

  Fly   279 FALQFVVPLGVLIFTYARITIRVWA--------------KRPPGEAETNR--------------- 314
            |.:.::.|||::...|.:|..::|.              |||..:.|...
  Rat   220 FFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFL 284

  Fly   315 -DQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLL---------LNDEEFAHWDPLPYVWFAF- 368
             :.:..|::||..||::.|::||..|:||.::|.:|         .:|.|..      |..|.|
  Rat   285 AEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAV------YACFTFS 343

  Fly   369 HWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVGDRMNATSGEMTTKYHRHVG 433
            |||..::...|||||.:::.:||..|.....        |||..:|...:|
  Rat   344 HWLVYANSAANPIIYNFLSGKFREQFKAAFS--------CCLPGLGPSSSA-------------- 386

  Fly   434 DALFRKPKICIRNGSSTSSQSNEHI 458
                |...:.:::..|.|..| ||:
  Rat   387 ----RHKSLSLQSRCSVSKVS-EHV 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	52/120 (43%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	92/301 (31%)
Hcrtr1	NP_037196.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Required for response to orexin-A. /evidence=ECO:0000250\|UniProtKB:O43613	26..41		4/14 (29%)
		7tmA_OXR	47..369	CDD:320336	100/328 (30%)
		TM helix 1	49..73	CDD:320336	9/23 (39%)
		TM helix 2	82..104	CDD:320336	9/21 (43%)
		TM helix 3	120..142	CDD:320336	10/21 (48%)
		TM helix 4	163..179	CDD:320336	5/15 (33%)
		TM helix 5	213..236	CDD:320336	5/22 (23%)
		TM helix 6	297..319	CDD:320336	9/21 (43%)
		TM helix 7	337..362	CDD:320336	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9048
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910