DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and Prokr2

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_659193.3	Gene:	Prokr2 / 246313	MGIID:	2181363	Length:	381	Species:	Mus musculus

Alignment Length:	342	Identity:	106/342 - (30%)
Similarity:	166/342 - (48%)	Gaps:	62/342 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VMMNFSCDDYDL-LSED---MWSSAYF--KIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVT 140
            |.:|:|..|||| |.||   ..:..:|  ||::.:....|.:...|||......:....::|.:|
Mouse    21 VSLNYSYGDYDLPLGEDEDVTKTQTFFAAKIVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLT 85

  Fly   141 NYFIASLAIGDILMSFFCVPSSFISLFILNY-------WPFGLALCHFVNYSQAVSVLVSAYTLV 198
            |..||:|||.|.|::..|.|      |.::|       |..|..||..|||.:.||:.||...|:
Mouse    86 NLLIANLAISDFLVAIVCCP------FEMDYYVVRQLSWAHGHVLCASVNYLRTVSLYVSTNALL 144

  Fly   199 AISIDRYIAIMWPLKPRITKRYATFIIAGVWFIALATALPIPIVSGLDIPMSPWHT--------- 254
            ||:||||:||:.|||||:..:.|:|:||.||.:::..|:|           |.:.|
Mouse   145 AIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAVP-----------SAYFTTETILVIVK 198

  Fly   255 KCEKYICREMWPSRTQEYY--YTLSLFALQFVVPLGVLIFTYARITIRVWAKRPPGEAETNRDQR 317
            ..||..|.::|....|.||  |.|.:|.|:||.|:..:...||||:..:|.|..|| .:|.:.::
Mouse   199 NQEKIFCGQIWSVDQQLYYKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPG-FQTEQIRK 262

  Fly   318 MARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFAHWDPLPYV----------WFAFHWLA 372
            ..|.:||.|.:::.::..:..||.||....::.        |..|.|          ::....:|
Mouse   263 RLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVR--------DFFPTVVVKEKHYLTAFYVVECIA 319

  Fly   373 MSHCCYNPIIYCYMNAR 389
            ||:...|.|  |::..:
Mouse   320 MSNSMINTI--CFVTVK 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	49/127 (39%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	90/288 (31%)
Prokr2	NP_659193.3	7tmA_prokineticin-R	51..341	CDD:320332	94/312 (30%)
		TM helix 1	52..78	CDD:320332	4/25 (16%)
		TM helix 2	85..110	CDD:320332	12/30 (40%)
		TM helix 3	125..155	CDD:320332	16/29 (55%)
		TM helix 4	166..187	CDD:320332	9/31 (29%)
		TM helix 5	217..246	CDD:320332	12/28 (43%)
		TM helix 6	265..295	CDD:320332	8/29 (28%)
		TM helix 7	309..334	CDD:320332	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910