DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and npr-12

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001293732.1	Gene:	npr-12 / 188742	WormBaseID:	WBGene00020689	Length:	397	Species:	Caenorhabditis elegans

Alignment Length:	398	Identity:	109/398 - (27%)
Similarity:	180/398 - (45%)	Gaps:	55/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 CDDYDLLSEDMWSSAYFKI------IVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIAS 146
            ||.:..:..  :.::.:||      ||.| |..:..|..:.|..|......|..:|.:.|.||.:
Worm    21 CDWFAEMQN--YQNSLYKINFDGSPIVPM-YGLVCSFGALANFIVLLAFVRTANLRNLRNSFIVN 82

  Fly   147 LAIGDILMSFFCVPSSFISLFI-LN-YWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIM 209
            ||..|:::   ||.::.::|:. || :||||...|.|:...|||:..||:.||..|::||.:..:
Worm    83 LAFSDLIL---CVVTAPVTLYTSLNLFWPFGDWSCKFLAGVQAVNTFVSSLTLAFIAMDRVLLTL 144

  Fly   210 WPLKPRITKRYATFIIAGVWFIALATALPIPI-VSGLDIPMSPWH--------TKCEKY---ICR 262
            .|::.|:...........||.|::..|||..: ||....|..||.        |.|.:.   ||.
Worm   145 CPVRWRLAATAPLLCYGVVWIISIIVALPYALAVSSKLAPFDPWSDRATPKMLTYCNRQVPEICA 209

  Fly   263 EM---WP----SRTQEYYYTLSLFALQFVVPLGVLIFTYARI--TIRVWAKRPPGEAETNRDQRM 318
            ||   |.    |:|.   ||..:..:|:::||..|.:.|.:|  ||:..:| .....:|.|..:|
Worm   210 EMQEAWDNAIVSKTT---YTFVVLGIQYILPLAALAYAYFQIGSTIQKRSK-VSRTVDTTRRMQM 270

  Fly   319 ARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIY 383
            ....|:.:.::..:|:.:..||.|.||.. :||..|..::....|::  .|.:.:|..|.|||:|
Worm   271 QNRNRRALLLLFLLVLTYAVCWAPMNIYH-VLNGLEIINYSQNMYIF--CHLVGISSTCVNPIVY 332

  Fly   384 CYMNARFRSGFVQLMHRMPGLRRWCCLRSVGDRMNATSGEMTTKYHRHVGDALFRKPKICIRNGS 448
            ..:|..||:....::.:.    |.|.:.:.|...........|....:|  .|.|.|       .
Worm   333 ALVNESFRNALQSMILQF----RPCYVTTTGTAATNVYAYSATSKAENV--TLMRDP-------F 384

  Fly   449 STSSQSNE 456
            ||:.:.||
Worm   385 STTPRPNE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	37/122 (30%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	84/283 (30%)
npr-12	NP_001293732.1	7tmA_NPYR-like	42..343	CDD:320331	93/311 (30%)
		TM helix 1	44..68	CDD:320331	7/24 (29%)
		TM helix 2	77..99	CDD:320331	8/24 (33%)
		TM helix 3	115..137	CDD:320331	9/21 (43%)
		TM helix 4	158..174	CDD:320331	5/15 (33%)
		TM helix 5	223..246	CDD:320331	7/25 (28%)
		TM helix 6	275..300	CDD:320331	7/25 (28%)
		TM helix 7	311..336	CDD:320331	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3897
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940