DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and npr-20

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_495888.3	Gene:	npr-20 / 188226	WormBaseID:	WBGene00011578	Length:	410	Species:	Caenorhabditis elegans

Alignment Length:	420	Identity:	99/420 - (23%)
Similarity:	169/420 - (40%)	Gaps:	120/420 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 ETYNITVMMNFSCDDYDLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVT 140
            :|:.|  :.|.:.|| |..|.......:.||.|.::|..:|:..|.||.....::.|.|.|||.|
Worm     4 DTFRI--ISNATLDD-DPCSVSFIDQPFVKIPVMIIYCLVFVVCLSGNFLTLIVMTSHPMMRTPT 65

  Fly   141 NYFIASLAIGDILMSFFCVPSSFISL--FILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISID 203
            |:|:::|||.|:|::.||:..:.|.:  |....||.|..:|........:....||..||.:|::
Worm    66 NFFLSNLAIADLLVAIFCILQNMIHIVGFDHGNWPLGPVMCKLYLGLTNIMPCTSAGILVLVSLE 130

  Fly   204 RYIAIMWPLK--PRITKRY---ATFIIAGVWFIALATALPIPIVSGLDIPMSPWHTKCEKY---- 259
            :|||::.||.  ..:|..:   ||.|   ||.|::....             |:....:.|
Worm   131 KYIAVLHPLSGLKLLTPEHRWVATMI---VWVISILVNF-------------PYFLYAQNYTYLG 179

  Fly   260 --IC----REMWPSRTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWA--------------- 303
              .|    ..:|.|.:         |.:.:::||..|:|.|:||:..:|.
Worm   180 VSACFRGSMPIWNSFS---------FIVWYLIPLTALVFIYSRISHLLWTSDSNRQSSRQSHESN 235

  Fly   304 ---KRPPGEAET--------------------------NRDQRMARSK--------RKMVKMMLT 331
               :|..|.|.|                          .|::::...|        ||:|::::.
Worm   236 GSLERGNGYANTAQPGSSWQMKNGRIVVYKQESLLNVPKREKKVKEPKRPKDTEGRRKVVRLLVA 300

  Fly   332 VVIVFTCCWLPFNILQL--------LLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNA 388
            ||:.|.....|.:...|        :.|......:.||.|: |.|...|:     |||:|..::.
Worm   301 VVVSFALLTFPHHARLLYTSFQTGTICNSNWTMIFQPLSYI-FLFISSAI-----NPILYACLSK 359

  Fly   389 RFRSGFVQLMHRMPGLRRWCCLRSVGDRMN 418
            |||:....::|         |.:.|..|::
Worm   360 RFRNALSDVIH---------CRKGVFSRIS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	42/127 (33%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	78/337 (23%)
npr-20	NP_495888.3	7tmA_Trissin_R	32..365	CDD:320140	86/363 (24%)
		TM helix 1	33..57	CDD:320140	6/23 (26%)
		TM helix 2	66..88	CDD:320140	9/21 (43%)
		TM helix 3	107..129	CDD:320140	4/21 (19%)
		TM helix 4	152..168	CDD:320140	6/31 (19%)
		TM helix 5	189..212	CDD:320140	7/31 (23%)
		TM helix 6	292..317	CDD:320140	7/24 (29%)
		TM helix 7	333..358	CDD:320140	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910