DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and npr-6

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_509725.2	Gene:	npr-6 / 185623	WormBaseID:	WBGene00009619	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	318	Identity:	96/318 - (30%)
Similarity:	163/318 - (51%)	Gaps:	34/318 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 YFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLF 167
            ||:.....:|..:|:.|..||..|.|:|.:..||:|:||.||.:||:.||::       :|.||:
Worm    35 YFRPFFISMYCAVFLVASSGNFLVVYVVMTNKRMQTITNIFITNLAVSDIMV-------NFTSLW 92

  Fly   168 I------LNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMW-----PLKPRITKRYA 221
            :      :.:|.||..|||.:...|..|:.:|.:||.||:|||||.|:.     .:..|::.|..
Worm    93 LTPTYTSIGHWIFGGGLCHGLPLFQGTSIFISTWTLTAIAIDRYIVIVHNSSNININDRMSMRSC 157

  Fly   222 TFIIAGVWFIALATALPIPIVSGLDIPMSPWHTKCEKYICREMWPSRTQEYYYTLSLFALQFVVP 286
            ...|..:|..:|....|..|    ::.::..|..|:..||.|.|.:......:.:.:..|||::|
Worm   158 LSFIVLIWLCSLLLVTPYAI----NMKLNYIHEPCDFLICSEDWSNAEFRSIFGIVVMILQFILP 218

  Fly   287 LGVLIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLL-- 349
            ..::..:|    |::|......::.|.|...:.|.|| :::|::.:|::|..||.|||:|..|
Worm   219 FVLIAISY----IKIWLFLNSRQSMTERKSDIKRKKR-LLRMLIVMVVIFAICWFPFNLLNCLRD 278

  Fly   350 LNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQ----LMHRMPG 403
            |..:.|.. ....:|:.:.|.::|:...:|||:|.:||..||..|.:    |..|.||
Worm   279 LKLDNFMR-GYFSFVFLSVHLMSMTATAWNPILYAFMNETFREEFAKVVPCLFARRPG 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	44/131 (34%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	81/273 (30%)
npr-6	NP_509725.2	7tmA_NPYR-like	39..322	CDD:320331	89/299 (30%)
		TM helix 1	40..64	CDD:320331	8/23 (35%)
		TM helix 2	73..95	CDD:320331	10/28 (36%)
		TM helix 3	111..133	CDD:320331	8/21 (38%)
		TM helix 4	159..175	CDD:320331	3/15 (20%)
		TM helix 5	204..227	CDD:320331	5/26 (19%)
		TM helix 6	250..275	CDD:320331	11/25 (44%)
		TM helix 7	290..315	CDD:320331	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5469
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102619
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.760