DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and npr-35

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001023088.1	Gene:	npr-35 / 183681	WormBaseID:	WBGene00016842	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	105/403 - (26%)
Similarity:	169/403 - (41%)	Gaps:	98/403 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 AYFKIIVY-MLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFIS 165
            :|...::| :.|..:|...::||..|...|::...:...|:|.|.|||:.|:.:.:.|:|::.|:
Worm    25 SYQLTVLYTVAYGAVFFTGVLGNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLPTTLIN 89

  Fly   166 LFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRIT--KRYATFIIAGV 228
             .|...|.:|...|....::.|.:...|.|||||::.|||:||...||...:  :.|..::|..|
Worm    90 -SIFTEWLWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYTKYVIFAV 153

  Fly   229 WFIALATALPIPIVSGLDIPMSPWHTKCEKY-ICREMWPSRT-QEYYYTLSLFALQFVVPLGVLI 291
            |.:|....:|    :..:..:..|......| :|    .|:| |:.|:......|.|:||.|::.
Worm   154 WLVAAIFGIP----NWYNYDLIVWQEGSYGYRLC----TSQTDQKLYFLFVNLLLAFIVPFGLIS 210

  Fly   292 FTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLP-------------- 342
            ..|.||.|.|...|........|:.|:   |.::..|||||:|||.|||||
Worm   211 GLYTRIFITVSTHRSLAVDARAREDRV---KLRVATMMLTVIIVFACCWLPLYCIFTYFFFFADQ 272

  Fly   343 ----FNILQLLLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPG 403
                |.|..:|:.        |:      |.|:::.....|||||...:.::|..|..:: .||
Worm   273 RSDLFQITSMLIR--------PI------FQWMSLLSSSLNPIIYIAYSHKYRRAFKSIL-LMP- 321

  Fly   404 LRRWCCLRSVGDRMNATSGEMTTKYHRHVGDALFRKPKICIRNGSSTSSQSNEHIHHLHQRSSKA 468
                 |               .|:|.| |...:.|:                      |.|..|:
Worm   322 -----C---------------KTRYER-VRSTILRR----------------------HSRGFKS 343

  Fly   469 TSDI----FASEP 477
            |:.|    |.:||
Worm   344 TATISMSNFGTEP 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	38/122 (31%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	81/282 (29%)
npr-35	NP_001023088.1	7tm_GPCRs	30..314	CDD:391938	87/309 (28%)
		TM helix 1	31..57	CDD:341315	7/25 (28%)
		TM helix 2	64..90	CDD:341315	10/26 (38%)
		TM helix 3	102..132	CDD:341315	12/29 (41%)
		TM helix 4	146..164	CDD:341315	5/21 (24%)
		TM helix 5	190..215	CDD:341315	7/24 (29%)
		TM helix 6	236..267	CDD:341315	15/33 (45%)
		TM helix 7	282..307	CDD:341315	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14687
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010