DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and tkr-2

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_500930.1	Gene:	tkr-2 / 183595	WormBaseID:	WBGene00016761	Length:	391	Species:	Caenorhabditis elegans

Alignment Length:	314	Identity:	96/314 - (30%)
Similarity:	154/314 - (49%)	Gaps:	27/314 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 IVYMLYIPIFIF-ALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILN 170
            |.|.:...:.|| ||:||.||.:|:....:||:||||::.:||:.|..:|.|....|    :..|
Worm    62 IFYGILFTLTIFLALMGNFTVMWIILYHRQMRSVTNYYLFNLAVADASISVFNTGFS----WSYN 122

  Fly   171 Y---WPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVWFIA 232
            |   |.||...|...|......:..|.:|::.:||:||.||:.|||.|..:|....||..:||:|
Worm   123 YYYVWKFGSFYCRINNLMGITPICASVFTMIVMSIERYYAIIHPLKKRPGRRSTVTIIIMIWFMA 187

  Fly   233 LATALPIPIVSGLDI-PMSPWHTKCEKYIC-REMWPSRTQE---YYYTLSLFALQFVVPLGVLIF 292
            ....:|..:.|.:|: .....:|..|..:| .:.:|...:.   ..|...|..:|:::||.:|..
Worm   188 FLFGVPAFLASKVDVYYFYDGYTLYENPLCLADNYPGGNESLLGQVYNNGLITVQYILPLCILSA 252

  Fly   293 TYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFAH 357
            .|.|:.:.:...:..|:.   |..:...:|:|...|:..||.:|...|.|:|...|.|:..|
Worm   253 AYYRVGVELRKDKTVGDV---RHAKSVAAKKKASIMLAVVVFIFMIVWFPYNAYYLTLHLVE--- 311

  Fly   358 WDPLP------YVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLR 405
              |:.      |::...:||.||...:||:||.:||.|||.||......:|.:|
Worm   312 --PIGNKMLSLYIYINIYWLGMSSTVFNPVIYYFMNKRFRVGFHHAFRWLPFVR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	46/124 (37%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	79/274 (29%)
tkr-2	NP_500930.1	7tmA_TACR	62..352	CDD:320512	92/301 (31%)
		TM helix 1	64..88	CDD:320512	10/23 (43%)
		TM helix 2	97..119	CDD:320512	8/25 (32%)
		TM helix 3	135..157	CDD:320512	3/21 (14%)
		TM helix 4	178..194	CDD:320512	5/15 (33%)
		TM helix 5	232..255	CDD:320512	6/22 (27%)
		TM helix 6	280..305	CDD:320512	8/24 (33%)
		TM helix 7	320..345	CDD:320512	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920