DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and npr-2

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_501701.2	Gene:	npr-2 / 177790	WormBaseID:	WBGene00003808	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	90/360 - (25%)
Similarity:	155/360 - (43%)	Gaps:	60/360 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SCDDYDLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGD 151
            :||.|.....||.:.....:...:||:.||:..::||..|.|:.....:::||.|.||.:|...:
Worm    51 TCDRYIDKHPDMTNEPTVLVTFSLLYLHIFLLGILGNSAVLYLTMKHRQLQTVQNIFILNLCASN 115

  Fly   152 ILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRI 216
            :||....:|.:||: .:...|.|...:|..:...|..|:.||.::|.||::|||..::.|.|.::
Worm   116 VLMCLTSLPITFIT-NVYKQWFFSSPVCKLIPLVQGASIFVSTFSLSAIALDRYNLVVRPHKQKL 179

  Fly   217 TKRYATFIIAGVWFIALATALP------IPIVSGLDIPMSPWHTKCEKYICREMWPSRTQEYYYT 275
            :.|.|..|...:|.|::...:|      :..::||          |.:| |.|.||.......||
Worm   180 SSRSAMMIALLIWVISVVVCMPYGWYMDVEKLNGL----------CGEY-CSEHWPLAEVRKGYT 233

  Fly   276 LSLFALQFVVPLGVLIFTY----ARITIRVWAKRPP------------------------GEAET 312
            ..:...||:.|...:.|.|    :|:..||..|...                        .||..
Worm   234 FLVLITQFLFPFATMAFCYYNIFSRLRQRVETKLKKLSERSQLLENSTTCGTTNHIVSINAEAVQ 298

  Fly   313 N---RDQRMA--RSKRKMVKMMLTVVIVFTCCWLPFNILQLLLN-DEEFAHWDPLP--------Y 363
            |   ..||:|  ..:|:...::..:|::|...|||.|::.|::. |..|.|.|...        .
Worm   299 NGLENKQRLAVLAQQRRTTTILSCMVLLFAFTWLPHNVVTLMIEYDGFFFHSDETSATSTDHTYI 363

  Fly   364 VWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLM 398
            |....|.::|.....||.:|.::|..|:...::.:
Worm   364 VSMTAHLISMLTNVTNPFLYAWLNPMFKEMLIKTL 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	37/120 (31%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	78/308 (25%)
npr-2	NP_501701.2	7tmA_NPYR-like	70..394	CDD:320331	85/335 (25%)
		TM helix 1	72..96	CDD:320331	8/23 (35%)
		TM helix 2	105..127	CDD:320331	7/21 (33%)
		TM helix 3	143..165	CDD:320331	7/21 (33%)
		TM helix 4	186..202	CDD:320331	3/15 (20%)
		TM helix 5	230..253	CDD:320331	6/22 (27%)
		TM helix 6	314..339	CDD:320331	7/24 (29%)
		TM helix 7	362..387	CDD:320331	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910