DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and tkr-3

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001343603.1	Gene:	tkr-3 / 177285	WormBaseID:	WBGene00006428	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	107/387 - (27%)
Similarity:	168/387 - (43%)	Gaps:	75/387 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 MNFSCDDYDLLS-----------------------EDMWSSAYFKIIVY-MLYIPIFIFALIGNG 124
            ||||..|..|.|                       :|.:.....::|:: |||..|...|::||.
Worm     1 MNFSATDSILASTITTVIGGAGVLAEAGEAELSGDDDFYELTPVELIIWCMLYAIIAFMAVVGNL 65

  Fly   125 TVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSF-ISLFILNYWPFGLALCHFVNYSQAV 188
            .|.||.....|:|::|.|||.:|...|:....|.:|..| .:||  ..|....:||..|.|.:.|
Worm    66 LVLYITLFRLRVRSITTYFILNLGFADLFTGIFAIPFKFQAALF--QEWFLPRSLCRIVPYVETV 128

  Fly   189 SVLVSAYTLVAISIDRYIAIMW----PLKPRITKRYATFIIAGVWFIALATALPIPIVSGLDIPM 249
            ::.||.:|||..::..:..:.:    .:.||..||....|    |.:|:..:||    .||
Worm   129 ALTVSVFTLVTSAVHEFRTMFFSKCSQMSPRSAKRCVLLI----WIMAVLVSLP----HGL---- 181

  Fly   250 SPWHTKCE--------KYICREMWPSRTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRP 306
              :|...|        ...|..::|.......|.:.|..:|:.||:.:|...|..|.:::|:.
Worm   182 --FHNTYEFPDDNNTSIVQCLPVYPDAGWWKTYNVYLVIIQYFVPMIILDTAYTMIAVKIWSL-- 242

  Fly   307 PGEAETNRDQ-RMARSKRKMVKM----------MLTVVIVFTC---CWLPFNILQLLLND--EEF 355
             .::....|: :||..|..:|.|          |.|::||..|   ||.|.. ..||||:  .|.
Worm   243 -SQSRVELDETKMATQKISVVSMVSPNTQLSQLMRTLIIVVACFSLCWFPLE-TYLLLNELKPEI 305

  Fly   356 AHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVGDRM 417
            ..|..:..|:|..||||||:.|.|||||...|.::...:.:|..::..:  |...:|:.|.|
Worm   306 NGWKYINLVFFFSHWLAMSNSCLNPIIYGLYNTKYNEEYRRLFRQIGCI--WQRQKSLDDSM 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	38/125 (30%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	85/289 (29%)
tkr-3	NP_001343603.1	7tm_GPCRs	47..344	CDD:391938	94/316 (30%)
		TM helix 1	48..74	CDD:341315	10/25 (40%)
		TM helix 2	81..106	CDD:341315	9/24 (38%)
		TM helix 3	119..149	CDD:341315	9/29 (31%)
		TM helix 4	160..181	CDD:341315	7/28 (25%)
		TM helix 5	209..238	CDD:341315	8/28 (29%)
		TM helix 6	254..299	CDD:341315	15/45 (33%)
		TM helix 7	312..337	CDD:341315	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910