Protein Alignment RYa-R and PROKR1

DIOPT Version :10

• Sequence 1: NP_001287552.1
• Gene: RYa-R / 43253
• FlyBaseID: FBgn0004842
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_620414.1
• Gene: PROKR1 / 10887
• HGNCID: 4524
• Length: 393
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 115/383 - (30%)
• Similarity: 185/383 - (48%)
• Gaps: 70/383 - (18%)

  Fly    56 DDEGSNYGYGSTTTLSGLQFETYNITVM-MNFSCDDYDL---LSEDMWSSAYF---KIIVYMLYI 113
            ||..:|   .||:.||.|.....:.|.. .|||..|||:   ..||:.:|..|   ||::.|..:
Human     9 DDNATN---TSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALV 70

  Fly   114 PIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILNY------- 171
            .|.:...|||......:....::|.:||..||:|||.|.|::..|.|      |.::|
Human    71 GIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCP------FEMDYYVVRQLS 129

  Fly   172 WPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVWFIALATA 236
            |..|..||..|||.:.||:.||...|:||:||||:||:.||:||:..:.||.:||.||.:::..|
Human   130 WEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIA 194

  Fly   237 LPIPIVSGLDIPMSPWHT---------KCEKYICREMWPSRTQEYY--YTLSLFALQFVVPLGVL 290
            :|           |.:.|         ..||..|.::||...|.||  |.|.:|.::||.|:..:
Human   195 IP-----------SAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTM 248

  Fly   291 IFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEF 355
            ...||||:..:|.|..|| .:|.:.::..|.:||.|.:::.::..:..||.||....::.:
Human   249 TLCYARISRELWFKAVPG-FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRD---- 308

  Fly   356 AHWDPLPYV--------WFAFHWLAMSHCCYNPIIYCYMNAR------FRSGFVQLMH 399
              :.|..:|        ::....:|||:...|.:  |::..:      |:.  :.|:|
Human   309 --FFPTVFVKEKHYLTAFYIVECIAMSNSMINTL--CFVTVKNDTVKYFKK--IMLLH 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tmA_PR4-like	106..394	CDD:320514	93/319 (29%)
		TM helix 1	107..133	CDD:320514	5/25 (20%)
		TM helix 2	140..165	CDD:320514	11/24 (46%)
		TM helix 3	179..209	CDD:320514	16/29 (55%)
		TM helix 4	220..241	CDD:320514	8/20 (40%)
		TM helix 5	271..300	CDD:320514	12/30 (40%)
		TM helix 6	320..350	CDD:320514	8/29 (28%)
		TM helix 7	362..387	CDD:320514	6/32 (19%)
PROKR1	NP_620414.1	7tmA_prokineticin-R	63..353	CDD:320332	92/315 (29%)
		TM helix 1	64..90	CDD:320332	5/25 (20%)
		TM helix 2	97..122	CDD:320332	12/30 (40%)
		TM helix 3	137..167	CDD:320332	16/29 (55%)
		TM helix 4	178..199	CDD:320332	9/31 (29%)
		TM helix 5	229..258	CDD:320332	11/28 (39%)
		TM helix 6	277..307	CDD:320332	8/29 (28%)
		TM helix 7	321..346	CDD:320332	5/26 (19%)