DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and qrfpra

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_021336543.1	Gene:	qrfpra / 100149491	ZFINID:	ZDB-GENE-090313-105	Length:	422	Species:	Danio rerio

Alignment Length:	432	Identity:	116/432 - (26%)
Similarity:	198/432 - (45%)	Gaps:	75/432 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YDLLSEDMWSSAYFKIIVY-------------MLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNY 142
            |:|..::...:...:.:||             ::|..||:.||:||..|.|||.....::|.||.
Zfish    18 YNLTRQEFIETYQIEPLVYIPELPAGAKTTFVIVYTVIFLLALVGNSVVVYIVLRKRGIQTATNI 82

  Fly   143 FIASLAIGDILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIA 207
            ||.|||:.|:|:||||:|.:.:. .|.:.|..|:.:|..|.:.|..:|:....|:..|:::||..
Zfish    83 FICSLAVSDLLISFFCIPFTLLQ-NISSEWFGGVLVCKTVPFVQTTAVVTGILTMTCIAVERYQG 146

  Fly   208 IMWPL--KPRITKRYATFIIAGVWFIALATALPIPIVSGLDIP---MSPWHTKCEKYICREMWPS 267
            |:.||  |.:.|.:.|..::..||..|:....|:..|..|::.   :...|..|    |:|.|.|
Zfish   147 IVHPLKIKRQCTPQRAYRMLGVVWIAAMMVGSPMLFVQQLEVKYDFLYDNHHVC----CQERWRS 207

  Fly   268 RTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPPGE-----AETNRD-QRMARSKRKMV 326
            ......|...:....|::||..::..|.||.|.:|.::..|:     |...|: .::||.||:.:
Zfish   208 SAHRKRYATFILVFLFLLPLAAMLILYTRIGIELWIRKQVGDSSVLNAMNQREVSKIARKKRRAI 272

  Fly   327 KMMLTVVIVFTCCWLPFNILQLLLNDEEFAH----WDPLP--YVWFAFHWLAMSHCCYNPIIYCY 385
            |||:|:|::||.||.||:.:.:|.   |:::    :|.:.  .:......:..|:...|||||.:
Zfish   273 KMMVTIVVLFTVCWAPFHTVHILF---EYSYLNKKYDDVTVNMIIAVAQAIGFSNSFNNPIIYAF 334

  Fly   386 MNARFRSGFVQLMHRMPGLRRWCCLRSVGDRMNATSGEMTTKYHRHVGDALFRKPKICIRNGSST 450
            ||..|:...:..:.        .|:|....|::.          :.....||.|          :
Zfish   335 MNENFQKNCMSTLS--------VCIRRSSHRVDV----------KDKSKVLFCK----------S 371

  Fly   451 SSQSNE-----HIHHLHQ----RSSKATSDIFASEPIIVRRD 483
            :.|..|     .||.:.|    ||:..||..|..|.:.|..:
Zfish   372 ARQDEEISVMPRIHIIDQVQYARSNMRTSMSFLEERMSVENN 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	45/122 (37%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	84/277 (30%)
qrfpra	XP_021336543.1	7tmA_QRFPR	46..343	CDD:320333	94/304 (31%)
		TM helix 1	47..73	CDD:320333	11/25 (44%)
		TM helix 2	80..106	CDD:320333	14/26 (54%)
		TM helix 3	118..148	CDD:320333	8/29 (28%)
		TM helix 4	161..182	CDD:320333	5/20 (25%)
		TM helix 5	211..236	CDD:320333	5/24 (21%)
		TM helix 6	266..296	CDD:320333	14/29 (48%)
		TM helix 7	311..336	CDD:320333	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910