DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and tacr1

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001106489.1	Gene:	tacr1 / 100127678	XenbaseID:	XB-GENE-5835469	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	130/381 - (34%)
Similarity:	195/381 - (51%)	Gaps:	38/381 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 MWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSS 162
            :||.|| .|||        |.:::||..|.:|:.:..|||||||||:.:||..:..||.|....:
Frog    34 LWSIAY-SIIV--------IVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVIN 89

  Fly   163 FISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAG 227
            | :..|.|:|.:||..|.|.|:....:|..|.|::.||::|||:||:.|||||::......:||.
Frog    90 F-TYAIHNHWYYGLIYCKFHNFFPISAVFSSIYSMTAIALDRYMAIIHPLKPRLSATATRIVIAV 153

  Fly   228 VWFIALATALPIPIVSGLDIPMSPWHTKCEKYICREMWP---SRTQEYYYTLSLFALQFVVPLGV 289
            :|..|.|.|.|    .|....:.|   ..::.:|...||   :|..|..|.:.||.|.:.:||.|
Frog   154 IWGFAFALAFP----QGYFATVEP---TPDRVVCYMEWPESENRKFEKVYQVLLFGLIYFLPLLV 211

  Fly   290 LIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNI---LQLLLN 351
            :..:|..|.:.:||...||:: ::|......:|||:||||:.||..|..||||::|   |||.|.
Frog   212 IGCSYTFIGMTLWASEIPGDS-SDRYHEQVVAKRKVVKMMIVVVCTFAICWLPYHIYFLLQLFLP 275

  Fly   352 DEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVGDR 416
            ||....:..|   :....||.||...|||||||.:|.|||.||..:.       |||.....|:.
Frog   276 DESQKFYQQL---YLGIMWLGMSSTMYNPIIYCCLNDRFRIGFKHVF-------RWCPFIHAGEY 330

  Fly   417 MNATSGEMTTKYHRHVGDALFRKPKICIRNGSSTSSQSNEHIHHLHQRSSKATSDI 472
            ...   ||.:..:.....::::..:| ....||..|.::|......:.|.:.:.|:
Frog   331 EGL---EMKSTRYLQTQSSMYKISRI-ETTVSSVLSANDEDAEETTKSSKRLSLDL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	47/120 (39%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	100/266 (38%)
tacr1	NP_001106489.1	7tmA_NK1R	33..315	CDD:320668	115/301 (38%)
		TM helix 1	34..60	CDD:320668	12/34 (35%)
		TM helix 2	67..93	CDD:320668	10/26 (38%)
		TM helix 3	105..135	CDD:320668	12/29 (41%)
		TM helix 4	146..167	CDD:320668	7/24 (29%)
		TM helix 5	193..222	CDD:320668	10/28 (36%)
		TM helix 6	241..271	CDD:320668	15/29 (52%)
		TM helix 7	283..308	CDD:320668	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920