DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6271 and PNLIP

DIOPT Version :9

Sequence 1:	NP_651526.1	Gene:	CG6271 / 43252	FlyBaseID:	FBgn0039476	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	279	Identity:	92/279 - (32%)
Similarity:	135/279 - (48%)	Gaps:	35/279 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GLTTVPVN------------FYLFTPKNPSSSKHIYATTKSISKSNFNPAHPTRFVIHGWTQSYL 114
            |:|..|::            |.|:|.:||::.:.:.|.:.|||.|||.....|||:|||:.....
Human    35 GITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGE 99

  Fly   115 NSMNSDIRKAFLSKGDYNVIVVDWARARSVDYATSVMAVAATGKKVAKMINFLKDNHGLNLNDVY 179
            .:..:::.|........|.|.|||.......|..:...:...|.:||..:.||:...|.:.::|:
Human   100 ENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVH 164

  Fly   180 VIGHSLGAHVAGYAGKNTDGQVHTIIGLDPALPLFSYNKPNKRLNSDDAWYVESIQTNGGTL--- 241
            |||||||||.||.||:.|:|.:..|.|||||.|.|.......||:..||.:|:.|.|:|..:
Human   165 VIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPN 229

  Fly   242 ---GFLKPIGKGAFYPNGGKTQPGCP-------LDVTG---------ACSHGRSTTYYAEA-VSE 286
               |..:.:|...|:||||...|||.       :|:.|         ||:|.||..||.:: |:.
Human   230 LGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNP 294

  Fly   287 DNFGTMKCGDYEEAVAKEC 305
            |.|....|..|....|.:|
Human   295 DGFAGFPCASYNVFTANKC 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6271	NP_651526.1	Lipase	57..337	CDD:278576	92/279 (33%)
CG6271	NP_651526.1	Pancreat_lipase_like	68..333	CDD:238363	89/273 (33%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	92/279 (33%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840