DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6271 and Lpl

DIOPT Version :9

Sequence 1:NP_651526.1 Gene:CG6271 / 43252 FlyBaseID:FBgn0039476 Length:341 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:312 Identity:96/312 - (30%)
Similarity:150/312 - (48%) Gaps:38/312 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 GRGLTTVPVNFYLFTPKNPSSSK-H-IYATTKSISKSNFNPAHPTRFVIHGWT-----QSYLNSM 117
            ||..:.:...|.|.||::.:... | |.....|:|..:||.:..|..||||||     :|::..:
  Rat    31 GRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKL 95

  Fly   118 NSDIRKAFLSKGDYNVIVVDWARARSVDYATSVMAVAATGKKVAKMINFLKDNHGLNLNDVYVIG 182
               :...:..:.|.|||||||.......|..|.......|..||:.||:|::.....|::|:::|
  Rat    96 ---VAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLG 157

  Fly   183 HSLGAHVAGYAGKNTDGQVHTIIGLDPALPLFSYNKPNKRLNSDDAWYVESIQT-----NGGTLG 242
            :|||||.||.||..|:.:|:.|.|||||.|.|.|.:...||:.|||.:|:.:.|     .|.::|
  Rat   158 YSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIG 222

  Fly   243 FLKPIGKGAFYPNGGKTQPGC---------------PLDVTGACSHGRSTTYYAEA-VSEDN-FG 290
            ..||:|....|||||..||||               .:|....|||.||...:.:: ::|:| ..
  Rat   223 IQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSK 287

  Fly   291 TMKCGD---YEEAVAKECGSTYSSVRMGADTNAYMVE--GDFYVPVNSKAPF 337
            ..:|..   :|:.:...|.....: .:|.:.|....:  ...|:...|:.|:
  Rat   288 AYRCNSKEAFEKGLCLSCRKNRCN-NVGYEINKVRAKRSSKMYLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6271NP_651526.1 Lipase 57..337 CDD:278576 95/310 (31%)
Pancreat_lipase_like 68..333 CDD:238363 92/298 (31%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 5/20 (25%)
lipo_lipase 33..472 CDD:132274 94/310 (30%)
Pancreat_lipase_like 37..334 CDD:238363 92/300 (31%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 2/22 (9%)
PLAT_LPL 341..465 CDD:238856
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338983
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.940

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