DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6271 and PNLIPRP3

DIOPT Version :9

Sequence 1:	NP_651526.1	Gene:	CG6271 / 43252	FlyBaseID:	FBgn0039476	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001011709.2	Gene:	PNLIPRP3 / 119548	HGNCID:	23492	Length:	467	Species:	Homo sapiens

Alignment Length:	324	Identity:	98/324 - (30%)
Similarity:	138/324 - (42%)	Gaps:	55/324 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WMEAQEKLEGRGLTTVPVNFYLFTPKNPSSSKHIYATTKS-ISKSNFNPAHPTRFVIHGWTQSYL 114
            |  :.||:..|        |.|:|..||::.:.|.|...| |..|.|.....||..|.||...
Human    47 W--SPEKINTR--------FLLYTIHNPNAYQEISAVNSSTIQASYFGTDKITRINIAGWKTD-- 99

  Fly   115 NSMNSDIRKAFLSKGDYNVIVVDWARARSVDYATSVMAVAATGKKVAKMINFLKDNHGLNLNDVY 179
            .....|:....|...|.|.|.:||... |.:|..:|..:...|.:||..|:.|......:.:.|:
Human   100 GKWQRDMCNVLLQLEDINCINLDWING-SREYIHAVNNLRVVGAEVAYFIDVLMKKFEYSPSKVH 163

  Fly   180 VIGHSLGAHVAGYAGKNTDGQVHTIIGLDPALPLFSYNKPNK-RLNSDDAWYVESIQTNGGTL-- 241
            :||||||||:||.||....| :..|.|||||.|.| :|.|.: ||:..||.:|:.|.||...:
Human   164 LIGHSLGAHLAGEAGSRIPG-LGRITGLDPAGPFF-HNTPKEVRLDPSDANFVDVIHTNAARILF 226

  Fly   242 ----GFLKPIGKGAFYPNGGKTQPGCPLDVTGA-----------------CSHGRSTTYYAEAV- 284
                |.:...|...|||||||..|||...:|..                 |:|.||..:|||::
Human   227 ELGVGTIDACGHLDFYPNGGKHMPGCEDLITPLLKFNFNAYKKEMASFFDCNHARSYQFYAESIL 291

  Fly   285 SEDNFGTMKCGDYEEAVAKECGSTYSSVRMGADTNAYMVE-----------GDFYVPVNSKAPF 337
            :.|.|....|..|....|..|   :...:.|..|..:..:           ..:::...|.:||
Human   292 NPDAFIAYPCRSYTSFKAGNC---FFCSKEGCPTMGHFADRFHFKNMKTNGSHYFLNTGSLSPF 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6271	NP_651526.1	Lipase	57..337	CDD:278576	94/316 (30%)
CG6271	NP_651526.1	Pancreat_lipase_like	68..333	CDD:238363	91/301 (30%)
PNLIPRP3	NP_001011709.2	Lipase	18..352	CDD:278576	96/322 (30%)
		Pancreat_lipase_like	52..348	CDD:238363	92/311 (30%)
		PLAT_PL	355..467	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840