DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6277 and PNLIP

DIOPT Version :9

Sequence 1:	NP_651525.1	Gene:	CG6277 / 43251	FlyBaseID:	FBgn0039475	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	267	Identity:	88/267 - (32%)
Similarity:	134/267 - (50%)	Gaps:	31/267 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 VPVKFYLYTSSNPTKGKKITASTKSIDASSFNSAHPTRFVIHGW----TQSYTASMNKDIRSAWL 126
            |..:|.|||:.||...:::.|.:.||..|:|.:...|||:|||:    .:::.|::.|::    .
Human    51 VNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNL----F 111

  Fly   127 SRGDYNVIVVDWARARSVDYATSVLAVAATGKKVAKMINFLKDNHGLNLNDLYVIGHSLGAHVAG 191
            .....|.|.|||.......|..:...:...|.:||..:.||:...|.:.::::|||||||||.||
Human   112 KVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAG 176

  Fly   192 YAGKNTDGQVHTIIGLDPALPLFSYNKPNKRLNSDDAWYVESIQTNGGTL------GFLKPIGKG 250
            .||:.|:|.:..|.|||||.|.|.......||:..||.:|:.|.|:|..:      |..:.:|..
Human   177 EAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHL 241

  Fly   251 AFYPNGGKTQPGCG-------LDLTG---------ACSHGRSTTYYAEA-VSEDNFGTMKCGDYE 298
            .|:||||...|||.       :|:.|         ||:|.||..||.:: |:.|.|....|..|.
Human   242 DFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYN 306

  Fly   299 EAVSKEC 305
            ...:.:|
Human   307 VFTANKC 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6277	NP_651525.1	Pancreat_lipase_like	68..333	CDD:238363	87/265 (33%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	88/267 (33%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840