DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6277 and LPL

DIOPT Version :9

Sequence 1:NP_651525.1 Gene:CG6277 / 43251 FlyBaseID:FBgn0039475 Length:341 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:328 Identity:97/328 - (29%)
Similarity:152/328 - (46%) Gaps:44/328 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 WMEAQELLESRG----------LTTVPVKFYLYTSSNPTKG--KKITASTKSIDASSFNSAHPTR 103
            |:  |.|..|||          ...:..||.|.|..:..:.  ..|....:|:....||.:..|.
Human    14 WL--QSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTF 76

  Fly   104 FVIHGWTQS--YTASMNKDIRSAWLSRGDYNVIVVDWARARSVDYATSVLAVAATGKKVAKMINF 166
            .||||||.:  |.:.:.|.:.:.:....|.|||||||.......|..|.......|:.||:.||:
Human    77 MVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINW 141

  Fly   167 LKDNHGLNLNDLYVIGHSLGAHVAGYAGKNTDGQVHTIIGLDPALPLFSYNKPNKRLNSDDAWYV 231
            :::.....|::::::|:|||||.||.||..|:.:|:.|.|||||.|.|.|.:...||:.|||.:|
Human   142 MEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFV 206

  Fly   232 ESIQT-----NGGTLGFLKPIGKGAFYPNGGKTQPGCGL---------------DLTGACSHGRS 276
            :.:.|     .|.::|..||:|....|||||..||||.:               |....|||.||
Human   207 DVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERS 271

  Fly   277 TTYYAEA-VSEDN-FGTMKCGD---YEEAVSKECGSTYSSVRMGADTNAYMVE--GDYYVPVNSK 334
            ...:.:: ::|:| ....:|..   :|:.:...|.....: .:|.:.|....:  ...|:...|:
Human   272 IHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCN-NLGYEINKVRAKRSSKMYLKTRSQ 335

  Fly   335 APF 337
            .|:
Human   336 MPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6277NP_651525.1 Pancreat_lipase_like 68..333 CDD:238363 89/295 (30%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 4/20 (20%)
Lipase 33..473 CDD:332983 91/307 (30%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 2/22 (9%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145305
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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