DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6277 and Lpl

DIOPT Version :9

Sequence 1:	NP_651525.1	Gene:	CG6277 / 43251	FlyBaseID:	FBgn0039475	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	308	Identity:	92/308 - (29%)
Similarity:	145/308 - (47%)	Gaps:	32/308 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RGLTTVPVKFYLYTSSNPTKG--KKITASTKSIDASSFNSAHPTRFVIHGWTQS--YTASMNKDI 121
            |..:.:..||.|.|..:..:.  ..|.....|:....||.:..|..||||||.:  |.:.:.|.:
Mouse    32 RDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLV 96

  Fly   122 RSAWLSRGDYNVIVVDWARARSVDYATSVLAVAATGKKVAKMINFLKDNHGLNLNDLYVIGHSLG 186
            .:.:....|.|||||||.......|..|.......|..||:.||::::.....|::::::|:|||
Mouse    97 AALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLG 161

  Fly   187 AHVAGYAGKNTDGQVHTIIGLDPALPLFSYNKPNKRLNSDDAWYVESIQT-----NGGTLGFLKP 246
            ||.||.||..|:.:|:.|.|||||.|.|.|.:...||:.|||.:|:.:.|     .|.::|..||
Mouse   162 AHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKP 226

  Fly   247 IGKGAFYPNGGKTQPGCGL---------------DLTGACSHGRSTTYYAEA-VSEDN-FGTMKC 294
            :|....|||||..||||.:               |....|||.||...:.:: ::|:| ....:|
Mouse   227 VGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRC 291

  Fly   295 GD---YEEAVSKECGSTYSSVRMGADTNAYMVE--GDYYVPVNSKAPF 337
            ..   :|:.:...|.....: .:|.:.|....:  ...|:...|:.|:
Mouse   292 NSKEAFEKGLCLSCRKNRCN-NLGYEINKVRAKRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6277	NP_651525.1	Pancreat_lipase_like	68..333	CDD:238363	89/295 (30%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		5/20 (25%)
		lipo_lipase	33..472	CDD:132274	91/307 (30%)
		Pancreat_lipase_like	37..334	CDD:238363	89/297 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		2/22 (9%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010