DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6283 and LPL

DIOPT Version :10

Sequence 1:NP_651524.1 Gene:CG6283 / 43250 FlyBaseID:FBgn0039474 Length:339 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:306 Identity:94/306 - (30%)
Similarity:135/306 - (44%) Gaps:58/306 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 PTDGKE-----IKAKSGSVEDSHFNKDHGTRFVIHGWTQRYSDDMNTRITKAWLSK--------- 125
            |.|..|     |...:.||...|||....|..||||||.       |.:.::|:.|         
Human    46 PEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTV-------TGMYESWVPKLVAALYKRE 103

  Fly   126 GDYNVIVVDWARARSVDYASSVLAVPGAGGKVGEMIKYLHDHHGLDYDSLEVIGHSLGAHVAGYA 190
            .|.|||||||.......|..|.......|..|...|.::.:......|::.::|:|||||.||.|
Human   104 PDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIA 168

  Fly   191 GKTVGDKRVHTIVGLDPALPLFSYDKPAKRLSTDDAHYVESIQT-----NGGKLGFLKPIGKGAF 250
            | ::.:|:|:.|.|||||.|.|.|.:...|||.|||.:|:.:.|     .|..:|..||:|....
Human   169 G-SLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDI 232

  Fly   251 YPNGGKSQPGCGL---------------DATGSCSHARSV-LYYAEAVTEDN-FGSIKCHD---Y 295
            |||||..||||.:               |....|||.||: |:....:.|:| ..:.:|..   :
Human   233 YPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAF 297

  Fly   296 EDAVAKNCGST------YSSVRMGAITNAYMVEGDFYVPVNSEAPF 335
            |..:..:|...      |...::.|..::.|     |:...|:.|:
Human   298 EKGLCLSCRKNRCNNLGYEINKVRAKRSSKM-----YLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6283NP_651524.1 Pancreat_lipase_like 65..331 CDD:238363 92/300 (31%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 3/6 (50%)
lipo_lipase 33..473 CDD:132274 94/306 (31%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 2/22 (9%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.

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