Protein Alignment CG6283 and LIPC

DIOPT Version :10

• Sequence 1: NP_651524.1
• Gene: CG6283 / 43250
• FlyBaseID: FBgn0039474
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 90/329 - (27%)
• Similarity: 144/329 - (43%)
• Gaps: 71/329 - (21%)

  Fly    60 ISTN------AVNFYVYTKSNPTDGKEIKAK-SGSVEDSHFNKDHGTRFVIHGWTQRYSDDMNTR 117
            :.||      ...|.::.::|  .|.:|:.. ..::::..||.......:||||:.       ..
Human    39 VETNKTLHEMKTRFLLFGETN--QGCQIRINHPDTLQECGFNSSLPLVMIIHGWSV-------DG 94

  Fly   118 ITKAWL----------SKGDYNVIVVDWARARSVDYASSVLAVPGAGGKVGEMIKYLHDHHGLDY 172
            :.:.|:          .....||.:|||.......|..:|......|.:|..::::|.:...|..
Human    95 VLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSR 159

  Fly   173 DSLEVIGHSLGAHVAGYAGKTV-GDKRVHTIVGLDPALPLFSYDKPAKRLSTDDAHYVESIQT-- 234
            ..:.:||:||||||:|:||.:: |..::..|.|||.|.|||....|:.|||.|||::|::|.|
Human   160 SHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFT 224

  Fly   235 ---NGGKLGFLKPIGKGAFYPNGGKSQPGC------------GLDA---TGSCSHARSVLYYAEA 281
               .|..:|..:|||...||||||..||||            |.:|   |..|||.|||..:.::
Human   225 REHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDS 289

  Fly   282 VTEDNFGSIKCHDYEDAVAKNCGSTYS-------SVRMGAI-TNAYMVEGD-------FYVPVNS 331
            :         .|....::|..||...|       |.:.|.. |..|.|..:       .::...:
Human   290 L---------LHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRA 345

  Fly   332 EAPF 335
            ::||
Human   346 QSPF 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6283	NP_651524.1	Pancreat_lipase_like	65..331	CDD:238363	86/312 (28%)
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	88/327 (27%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		4/22 (18%)
		PLAT_LPL	352..487	CDD:238856