DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17191 and Lpl

DIOPT Version :9

Sequence 1:NP_651523.1 Gene:CG17191 / 43249 FlyBaseID:FBgn0039473 Length:337 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:292 Identity:90/292 - (30%)
Similarity:136/292 - (46%) Gaps:55/292 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 ASSIEDSHFDKNQGTRFVIHGW--NGRYTDGMNVKITRAWLSKGDYNVIVVNW-DRAQ-----SV 139
            |.|:.:.||:.:..|..|||||  .|.|...:...:...:..:.|.|||||:| .|||     |.
  Rat    61 ADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSA 125

  Fly   140 DYISSVRAVPGAGAKVGEMIEYLHEHHHLSMESLEVIGHSLGAHVAGYAGKQVGGKRVHTIVGLD 204
            .|...|      |..|...|.:|.|..:..::::.::|:|||||.||.|| .:..|:|:.|.|||
  Rat   126 GYTKLV------GNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAG-SLTNKKVNRITGLD 183

  Fly   205 PAMPLFAYDKPDKRLSTEDAFYVESIQT-----NGGEKGFLKPIGKGTFYPNGGRNQPGCGSDIG 264
            ||.|.|.|.:...|||.:||.:|:.:.|     .|...|..||:|....|||||..||||  :||
  Rat   184 PAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGC--NIG 246

  Fly   265 GT-----------------CAHGRSVTYYVEA-VTEDN-FGTIKCHDYQA--------ALANECG 302
            ..                 |:|.||:..:::: :.|:| ....:|:..:|        ...|.|.
  Rat   247 EAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCN 311

  Fly   303 ST-YSGVRMGAVTNAYMVDGDFYVPVNGQAPF 333
            :. |...::.|..::.|     |:....|.|:
  Rat   312 NVGYEINKVRAKRSSKM-----YLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17191NP_651523.1 Pancreat_lipase_like 62..328 CDD:238363 88/285 (31%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53
lipo_lipase 33..472 CDD:132274 90/292 (31%)
Pancreat_lipase_like 37..334 CDD:238363 88/286 (31%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 3/24 (13%)
PLAT_LPL 341..465 CDD:238856
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338986
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.940

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