DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17192 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_651522.1	Gene:	CG17192 / 43248	FlyBaseID:	FBgn0039472	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	321	Identity:	100/321 - (31%)
Similarity:	147/321 - (45%)	Gaps:	38/321 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAALLVAGNALPIEERINGENGWFVPQED--GTFQWMDKKDAKELLENISPLEFRSNEVSFYLYT 69
            |..||:|  .:..:|...|:.|.|..::.  ||.|    :..|.|     |......:..|.|||
Human     7 LGLLLLA--TVRGKEVCYGQLGCFSDEKPWAGTLQ----RPVKLL-----PWSPEDIDTRFLLYT 60

  Fly    70 KQNPTEGQEIT-ADASSIVASHFNKDHGTRFVIHGWKGKYTDSMNVDITKAWLSKGDFNVIVVNW 133
            .:||...|.|| .:..:|.||:|..|..|||:|||:..|..||...|:.|........|.|.|:|
Human    61 NENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNCICVDW 125

  Fly   134 ARSQSVDYAMSVRAVPGAGTKVGEMIQYMHENHDMSLETLEVIGHSLGAHVAGYAGKQVGQKRVH 198
            .......|..:|:.:...|.:...:||.:......|||.:.|||||||||.|..||:::| .||.
Human   126 RHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLG-GRVG 189

  Fly   199 TIVGLDPALPLFSYDNPDKRLSSEDAFYVESIQTNGGV------KGFVKPIGKAAFYVSGGRKQP 257
            .|.|||||.|.|..:..:.||...||.:|:.|.|:...      .|..:.:|...|:.:||::.|
Human   190 RITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMP 254

  Fly   258 GCGVDLAGT----------------CSHARSVIYYAEAI-TENSFGAIQCQDYQAALDNEC 301
            ||..::..|                |:|.||..||:.:: ..:.|....|..|....:::|
Human   255 GCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKC 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17192	NP_651522.1	Lipase	55..333	CDD:278576	87/271 (32%)
CG17192	NP_651522.1	Pancreat_lipase_like	62..329	CDD:238363	86/264 (33%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	96/308 (31%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		6/11 (55%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		1/21 (5%)
		PLAT_PL	357..469	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940