DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17192 and Lpl

DIOPT Version :9

Sequence 1:NP_651522.1 Gene:CG17192 / 43248 FlyBaseID:FBgn0039472 Length:337 Species:Drosophila melanogaster
Sequence 2:NP_032535.2 Gene:Lpl / 16956 MGIID:96820 Length:474 Species:Mus musculus


Alignment Length:314 Identity:95/314 - (30%)
Similarity:133/314 - (42%) Gaps:45/314 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 EFRSNEVSFYLYTKQNPTEG--QEITADASSIVASHFNKDHGTRFVIHGW--KGKYTDSMNVDIT 117
            :|...|..|.|.|.::..|.  ..|...|.|:...|||....|..|||||  .|.|...:...:.
Mouse    33 DFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVA 97

  Fly   118 KAWLSKGDFNVIVVNWARSQSVDYAMSVRAVPGAGTKVGEMIQYMHENHDMSLETLEVIGHSLGA 182
            ..:..:.|.|||||:|.......|.:|.......|..|...|.:|.|..:..|:.:.::|:||||
Mouse    98 ALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGA 162

  Fly   183 HVAGYAGKQVGQKRVHTIVGLDPALPLFSYDNPDKRLSSEDAFYVESIQT-----NGGVKGFVKP 242
            |.||.|| .:..|:|:.|.|||||.|.|.|.....|||.:||.:|:.:.|     .|...|..||
Mouse   163 HAAGVAG-SLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKP 226

  Fly   243 IGKAAFYVSGGRKQPGCG---------------VDLAGTCSHARSVIYYAEAI--TENSFGAIQC 290
            :|....|.:||..||||.               ||....|||.||:..:.:::  .||...|.:|
Mouse   227 VGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRC 291

  Fly   291 QDYQA--------ALDNEC---GSSFSSVRMAEDTNAYNVEGHFYVPVNSEAPF 333
            ...:|        ...|.|   |...:.||....:.       .|:...|:.|:
Mouse   292 NSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSK-------MYLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17192NP_651522.1 Lipase 55..333 CDD:278576 94/312 (30%)
Pancreat_lipase_like 62..329 CDD:238363 92/303 (30%)
LplNP_032535.2 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 6/19 (32%)
lipo_lipase 33..472 CDD:132274 95/314 (30%)
Pancreat_lipase_like 37..334 CDD:238363 92/304 (30%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 3/22 (14%)
PLAT_LPL 341..465 CDD:238856
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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