DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6295 and PNLIP

DIOPT Version :9

Sequence 1:	NP_651521.1	Gene:	CG6295 / 43247	FlyBaseID:	FBgn0039471	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	268	Identity:	99/268 - (36%)
Similarity:	129/268 - (48%)	Gaps:	40/268 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 FYLYTNSNRNSPQEIKATSASISGSHFNPNHPTRFTIHGWSSSKDEFINYGVRDAW--------F 122
            |.||||.|.|:.||:.|.|:|||||:|..|..|||.|||       ||:.| .:.|        |
Human    55 FLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHG-------FIDKG-EENWLANVCKNLF 111

  Fly   123 THGDMNMIAVDWGRARSVDYASSVLAVPGVGEQVATLINFMRSNHGLNLDNTMVIGHSLGAHVSG 187
            ....:|.|.|||.......|..:...:..||.:||..:.|::|..|.:..|..|||||||||.:|
Human   112 KVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAG 176

  Fly   188 YAGKNVKNGQLHTIIGLDPALPLFSYDSPNKRLSSTDAYYVESIQTNGGTL------GFLKPIGK 246
            .||:.. ||.:..|.|||||.|.|.......||..:||.:|:.|.|:|..:      |..:.:|.
Human   177 EAGRRT-NGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGH 240

  Fly   247 GAFYPNGGKSQPGCG-------VDLTG---------SCAHSRSVIYYAES-VTENNFPTMRCGDY 294
            ..|:||||...|||.       ||:.|         :|.|.||..||.:| |..:.|....|..|
Human   241 LDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASY 305

  Fly   295 EEAVAKEC 302
            ....|.:|
Human   306 NVFTANKC 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6295	NP_651521.1	Pancreat_lipase_like	64..330	CDD:238363	99/268 (37%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	99/268 (37%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145318
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840