DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6295 and Lipc

DIOPT Version :9

Sequence 1:	NP_651521.1	Gene:	CG6295 / 43247	FlyBaseID:	FBgn0039471	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	XP_006510879.1	Gene:	Lipc / 15450	MGIID:	96216	Length:	526	Species:	Mus musculus

Alignment Length:	397	Identity:	107/397 - (26%)
Similarity:	168/397 - (42%)	Gaps:	99/397 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MKLFLALAFCVLAANAVEVRVNGENGWYVPQADGTMEWMDREFAEAYLETKNRMEGRNVL-NPVT 65
            :::.:.|.||:...::.           ..|..||         |.:..:....|....| .|.|
Mouse     5 LQISIFLVFCIFIQSSA-----------CGQGVGT---------EPFGRSLGATEASKPLKKPET 49

  Fly    66 -FYLYTNSN-----RNSPQEIKATSASISGSHFNPNHPTRFTIHGWSSS------KDEFINY--- 115
             |.|:.:.|     |..||.    ..::....||.:.|....|||||.|      ||...:|
Mouse    50 RFLLFQDENDRLGCRLRPQH----PETLQECGFNSSQPLIMIIHGWSGSESATVGKDSDSDYQVD 110

  Fly   116 GVRDAWF----------THGDMNMIAVDWGRARSVDYASSVLAVPG---VGEQVATLINFMRSNH 167
            |:.:.|.          ....:|:..|||   .|:.|....:||..   ||:.||.|:.::..:.
Mouse   111 GLLENWIWKIVSALKSRQSQPVNVGLVDW---ISLAYQHYTIAVQNTRIVGQDVAALLLWLEESA 172

  Fly   168 GLNLDNTMVIGHSLGAHVSGYAGKNV--KNGQLHTIIGLDPALPLFSYDSPNKRLSSTDAYYVES 230
            ..:.....:||:||||||||:||.::  || ::..|.|||||.|:|...|||:|||..||.:|::
Mouse   173 KFSRSKVHLIGYSLGAHVSGFAGSSMDGKN-KIGRITGLDPAGPMFEGTSPNERLSPDDANFVDA 236

  Fly   231 IQT-----NGGTLGFLKPIGKGAFYPNGGKSQPGC---------------GVDLTGSCAHSRSVI 275
            |.|     .|.::|..:||....||||||..||||               .:..|..|||.|||.
Mouse   237 IHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTIKCAHERSVH 301

  Fly   276 YYAESVTENNFPTM--RC---GDYEEAVAKEC--------GSSYSSVRMGATTNAYMVAGDYYVP 327
            .:.:|:..::..::  :|   |.:.:.:...|        |......|.|.:...:::
Mouse   302 LFIDSLQHSDLQSIGFQCSDMGSFSQGLCLSCKKGRCNTLGYDIRKDRSGKSKRLFLI------- 359

  Fly   328 VRSDAPY 334
            .|:.:|:
Mouse   360 TRAQSPF 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6295	NP_651521.1	Pancreat_lipase_like	64..330	CDD:238363	95/328 (29%)
Lipc	XP_006510879.1	Lipase	18..366	CDD:333880	103/382 (27%)
Lipc	XP_006510879.1	PLAT_LPL	369..504	CDD:238856
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840