DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6296 and LPL

DIOPT Version :9

Sequence 1:NP_651520.1 Gene:CG6296 / 43246 FlyBaseID:FBgn0039470 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:381 Identity:107/381 - (28%)
Similarity:164/381 - (43%) Gaps:62/381 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 GKAEAERQLEYYEAQEALEGRLSTNTVNFYLYTLQNPSTGQQIKATQDSIDGSFFNPQNPTRITI 109
            |.|.|:::.::.:.:.....|...:|..         .|...|....:|:....||..:.|.:.|
Human    24 GVAAADQRRDFIDIESKFALRTPEDTAE---------DTCHLIPGVAESVATCHFNHSSKTFMVI 79

  Fly   110 HGW--NSNYKDGVNTRVADAWFQYGDYNMIAVDWLRGRSLEYASSVAGAPGAGKKVAALVDFLVE 172
            |||  ...|:..|...||..:.:..|.|:|.||||......|..|.......|:.||..::::.|
Human    80 HGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEE 144

  Fly   173 GYGMSLDTLEIVGFSLGAHVAGHTAKQVNSGKVGKVVGLDPASPLISYSNTEKRLSSDDALYVES 237
            .:...||.:.::|:|||||.|| .|..:.:.||.::.|||||.|...|:....|||.|||.:|:.
Human   145 EFNYPLDNVHLLGYSLGAHAAG-IAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDV 208

  Fly   238 IQT-----NGAILGFGQPIGKASFYMNGGRSQPGCGI---------------DITGSCSHTKAVL 282
            :.|     .|..:|..:|:|....|.|||..||||.|               |....|||.:::.
Human   209 LHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIH 273

  Fly   283 YYVEALLWNNFPS--IKCESS--------VDANKNNCGNTYSSVFMGASINFFVAE--GIFYVPV 335
            .::::||....||  .:|.|.        :...||.|.|      :|..||...|:  ...|:..
Human   274 LFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNN------LGYEINKVRAKRSSKMYLKT 332

  Fly   336 NKESPYGLGELN-----SGGEATTGTPE-----ITSTTVDGEDESTT--EVSTSTT 379
            ..:.||.:....     ||.|:.|.|.:     :..|..:.|:...|  ||||:.|
Human   333 RSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKT 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6296NP_651520.1 Pancreat_lipase_like 71..337 CDD:238363 87/299 (29%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 2/29 (7%)
Lipase 33..473 CDD:332983 104/372 (28%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 3/22 (14%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145311
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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