Protein Alignment CG6296 and Lpl

DIOPT Version :10

• Sequence 1: NP_651520.1
• Gene: CG6296 / 43246
• FlyBaseID: FBgn0039470
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_036730.1
• Gene: Lpl / 24539
• RGDID: 3017
• Length: 474
• Species: Rattus norvegicus
• Alignment Length: 392
• Identity: 109/392 - (27%)
• Similarity: 161/392 - (41%)
• Gaps: 70/392 - (17%)

  Fly    39 GGLRWIGKAEAERQLEYYEAQEALEGRLSTNTVNFYLYTLQNPSTGQQIKATQDSIDGSFFNPQN 103
            ||   :..|:..|.....|::.||  |...:|..         .|...|....||:....||..:
  Rat    23 GG---VAAADGGRDFSDIESKFAL--RTPEDTAE---------DTCHLIPGLADSVSNCHFNHSS 73

  Fly   104 PTRITIHGW--NSNYKDGVNTRVADAWFQYGDYNMIAVDWLRGRSLEYASSVAGAPGAGKKVAAL 166
            .|.:.||||  ...|:..|...||..:.:..|.|:|.||||......|..|.......|..||..
  Rat    74 KTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARF 138

  Fly   167 VDFLVEGYGMSLDTLEIVGFSLGAHVAGHTAKQVNSGKVGKVVGLDPASPLISYSNTEKRLSSDD 231
            :::|.|.:...||.:.::|:|||||.|| .|..:.:.||.::.|||||.|...|:....|||.||
  Rat   139 INWLEEEFNYPLDNVHLLGYSLGAHAAG-VAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDD 202

  Fly   232 ALYVESIQT-----NGAILGFGQPIGKASFYMNGGRSQPGCGI---------------DITGSCS 276
            |.:|:.:.|     .|..:|..:|:|....|.|||..||||.|               |....||
  Rat   203 ADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCS 267

  Fly   277 HTKAVLYYVEALLWNNFPS--IKCESS--------VDANKNNCGNTYSSVFMGASINFFVAE--G 329
            |.:::..::::||....||  .:|.|.        :...||.|.|      :|..||...|:  .
  Rat   268 HERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNN------VGYEINKVRAKRSS 326

  Fly   330 IFYVPVNKESPYGL----GELNSGGEATTGTPEITSTTVDGEDESTTEVSTSTTTDKPEESTTEE 390
            ..|:....:.||.:    .:::..|           |..|.::....|:|...|..:.|......
  Rat   327 KMYLKTRSQMPYKVFHYQVKIHFSG-----------TENDKQNNQAFEISLYGTVAESENIPFTL 380

  Fly   391 PE 392
            ||
  Rat   381 PE 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6296	NP_651520.1	Pancreat_lipase_like	71..337	CDD:238363	89/299 (30%)
		MSCRAMM_ClfA	<334..621	CDD:468110	11/63 (17%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	32..53		6/31 (19%)
		lipo_lipase	33..472	CDD:132274	105/379 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858	243..266		3/22 (14%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	443..467