DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6296 and Lpl

DIOPT Version :9

Sequence 1:	NP_651520.1	Gene:	CG6296 / 43246	FlyBaseID:	FBgn0039470	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	423	Identity:	120/423 - (28%)
Similarity:	173/423 - (40%)	Gaps:	86/423 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LCLLVLGCVIAASAWPVDQLSVRDHGINGWFVPQREGGLRWIGKAEAERQLEYYEAQEALEGRLS 67
            |.|:|||      .|.....:.|             ||   :..|:|.|.....|::.||  |..
Mouse     6 LLLVVLG------VWLQSLTAFR-------------GG---VAAADAGRDFSDIESKFAL--RTP 46

  Fly    68 TNTVNFYLYTLQNPSTGQQIKATQDSIDGSFFNPQNPTRITIHGW--NSNYKDGVNTRVADAWFQ 130
            .:|..         .|...|....||:....||..:.|.:.||||  ...|:..|...||..:.:
Mouse    47 EDTAE---------DTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly   131 YGDYNMIAVDWLRGRSLEYASSVAGAPGAGKKVAALVDFLVEGYGMSLDTLEIVGFSLGAHVAGH 195
            ..|.|:|.||||......|..|.......|..||..::::.|.:...||.:.::|:|||||.||
Mouse   103 EPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAG- 166

  Fly   196 TAKQVNSGKVGKVVGLDPASPLISYSNTEKRLSSDDALYVESIQT-----NGAILGFGQPIGKAS 255
            .|..:.:.||.::.|||||.|...|:....|||.|||.:|:.:.|     .|..:|..:|:|...
Mouse   167 VAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVD 231

  Fly   256 FYMNGGRSQPGCGI---------------DITGSCSHTKAVLYYVEALLWNNFPS--IKCESS-- 301
            .|.|||..||||.|               |....|||.:::..::::||....||  .:|.|.
Mouse   232 IYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEA 296

  Fly   302 ------VDANKNNCGNTYSSVFMGASINFFVAE--GIFYVPVNKESPYGLGELN-----SG---G 350
                  :...||.|.|      :|..||...|:  ...|:....:.||.:....     ||   |
Mouse   297 FEKGLCLSCRKNRCNN------LGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTEDG 355

  Fly   351 EATTGTPEIT--STTVDGEDESTT--EVSTSTT 379
            :......||:  .|..:.|:...|  ||||:.|
Mouse   356 KQHNQAFEISLYGTVAESENIPFTLPEVSTNKT 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6296	NP_651520.1	Pancreat_lipase_like	71..337	CDD:238363	88/299 (29%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		6/31 (19%)
		lipo_lipase	33..472	CDD:132274	108/374 (29%)
		Pancreat_lipase_like	37..334	CDD:238363	93/314 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		3/22 (14%)
		PLAT_LPL	341..465	CDD:238856	13/48 (27%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010