DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and ALD5

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_010996.2	Gene:	ALD5 / 856804	SGDID:	S000000875	Length:	520	Species:	Saccharomyces cerevisiae

Alignment Length:	473	Identity:	228/473 - (48%)
Similarity:	319/473 - (67%)	Gaps:	4/473 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTN 100
            ||||.|||.|...|||...||:..::|..|.:..:.|:|.||.||||||  :::|..:.|..|..
Yeast    46 LFINGEFVASKQKKTFDVINPSNEEKITTVYKAMEDDVDEAVAAAKKAF--ETKWSIVEPEVRAK 108

  Fly   101 LMNKLCALMDRDKAFLASLETQDNGKPYAEALFDVTYSILTLQYYAGWTDKFFGDTIPAG-GFVS 164
            .:..|..|:::.:..||::|:.||||....|..||......|:...||.||.:|:.|..| ...:
Yeast   109 ALFNLADLVEKHQETLAAIESMDNGKSLFCARGDVALVSKYLRSCGGWADKIYGNVIDTGKNHFT 173

  Fly   165 MTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAGV 229
            .:.|||:||.|||||||:||||.:||.|||||.|.|:::||||.|||:||..:.|.:|||.||||
Yeast   174 YSIKEPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKPAETTPLSALFASQLCQEAGIPAGV 238

  Fly   230 INVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDAD 294
            :|::.|.|...|..:|||||:.|:|||||...||.:|:.|| ..:|:|:||||||||.:||.|||
Yeast   239 VNILPGSGRVVGERLSAHPDVKKIAFTGSTATGRHIMKVAA-DTVKKVTLELGGKSPNIVFADAD 302

  Fly   295 IDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQIDD 359
            :|.||:.....:|.|.|:.||||||.|:.:.:|:|.:.|.....::.|||:||::.|.||.|..|
Yeast   303 LDKAVKNIAFGIFYNSGEVCCAGSRIYIQDTVYEEVLQKLKDYTESLKVGDPFDEEVFQGAQTSD 367

  Fly   360 DMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSS 424
            ..|.|:|.|::..|.|||:|..||.|.|:.|:||:||||:|||:||||.:||:|||:.::.|||:
Yeast   368 KQLHKILDYVDVAKSEGARLVTGGARHGSKGYFVKPTVFADVKEDMRIVKEEVFGPIVTVSKFST 432

  Fly   425 LEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKHSGIGREL 489
            ::|:|..||:.|||||||:.|||||||:..:..|.||:||||.|:....:.||||:..||||||:
Yeast   433 VDEVIAMANDSQYGLAAGIHTNDINKAVDVSKRVKAGTVWINTYNNFHQNVPFGGFGQSGIGREM 497

  Fly   490 GKDGLDNYLETKTITMKL 507
            |:..|.||.:||::.:.:
Yeast   498 GEAALSNYTQTKSVRIAI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	228/470 (49%)
ALD5	NP_010996.2	ALDH_F1-2_Ald2-like	41..513	CDD:143410	228/469 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	472	1.000	Inparanoid score	I229
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		mtm9192
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
TreeFam	0	0.000	Not matched by this tool.
	12	11.900