DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and MSC7

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_011904.1	Gene:	MSC7 / 856434	SGDID:	S000001081	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	135/517 - (26%)
Similarity:	221/517 - (42%)	Gaps:	70/517 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLS 94
            |||:.|...                 |||.:.:.......:||||..|..|.||   .|.|....
Yeast   108 EPNFIQCHC-----------------PATGQYLGSFPSKTEADIDEMVSKAGKA---QSTWGNSD 152

  Fly    95 PLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEA-LFDVTYSILTLQYYAGWTDKFFGDTI- 157
            ..:|..::..|...:..::..:|.:..:|:||...:| :.::..::..:|    ||.|.....:
Yeast   153 FSRRLRVLASLHDYILNNQDLIARVACRDSGKTMLDASMGEILVTLEKIQ----WTIKHGQRALQ 213

  Fly   158 ------PAGGFV-----SMTRKEPVGVVGQIIPWNYPLLMLAWKWGP---ALAVGCTIIMKPAEQ 208
                  |...|:     :..|.||:||:..|:.||||...|.   ||   ||..|..|::|.:||
Yeast   214 PSRRPGPTNFFMKWYKGAEIRYEPLGVISSIVSWNYPFHNLL---GPIIAALFTGNAIVVKCSEQ 275

  Fly   209 TPLTALHMAALAKE----AGFPAGVINVVNGFGPT----AGAAISAHPDIAKVAFTGSVEIGRIV 265
            ...::.....|.::    ......::.:.....||    :....::||....:.|.||..:...:
Yeast   276 VVWSSEFFVELIRKCLEACDEDPDLVQLCYCLPPTENDDSANYFTSHPGFKHITFIGSQPVAHYI 340

  Fly   266 MQAAATSNLKRVSLELGGKSPVVVFDDA-DIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDE 329
            ::.||.| |..|.:|||||...:|.|.| ::|..........|.:.||:|....|..|.::.||:
Yeast   341 LKCAAKS-LTPVVVELGGKDAFIVLDSAKNLDALSSIIMRGTFQSSGQNCIGIERVIVSKENYDD 404

  Fly   330 FVAKAAAKAKARKVGNPFEQ--------NVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRI 386
            .|    .....|...||..|        ||..|..|.|:...::...::....:||:|..||.|.
Yeast   405 LV----KILNDRMTANPLRQGSDIDHLENVDMGAMISDNRFDELEALVKDAVAKGARLLQGGSRF 465

  Fly   387 GN----VGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITND 447
            .:    .|.:.:||:..||..:|:|||.|:|||:..:.|..:.:..:..||:..:||...|...|
Yeast   466 KHPKYPQGHYFQPTLLVDVTPEMKIAQNEVFGPILVMMKAKNTDHCVQLANSAPFGLGGSVFGAD 530

  Fly   448 INKALKFANNVDAGSVWINCYDA-VLPSTPFGGYKHSGIGRELGKDGLDNYLETKTITMKLL 508
            |.:....||::..|:|.||.:.. .:...||||...||.|:..|::||......|::....|
Yeast   531 IKECNYVANSLQTGNVAINDFATFYVCQLPFGGINGSGYGKFGGEEGLLGLCNAKSVCFDTL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	131/510 (26%)
MSC7	NP_011904.1	ALDH_F15-22	115..590	CDD:143416	130/506 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S334
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760