DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and aldh1a3

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001038210.1	Gene:	aldh1a3 / 751785	ZFINID:	ZDB-GENE-061128-2	Length:	513	Species:	Danio rerio

Alignment Length:	480	Identity:	269/480 - (56%)
Similarity:	345/480 - (71%)	Gaps:	2/480 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLS 94
            |..:.::|||||:..|..||.|.|.||||..:|..:.|.||||:|.||||||.|..|.|.||::.
Zfish    28 EIKHTKIFINNEWHTSSKGKQFPTINPATGVKICDIEEADKADVDEAVKAAKAAGQRGSVWRRMD 92

  Fly    95 PLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEALF-DVTYSILTLQYYAGWTDKFFGDTIP 158
            ...|..|:|:|..|::|::|.||:||::|.|||:..|.| |:..||.||:||||||||..|.|:|
Zfish    93 ASSRGRLLNRLADLLERERAVLATLESKDTGKPFLHAFFVDLDGSIKTLRYYAGWTDKIHGKTMP 157

  Fly   159 AG-GFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKE 222
            .. .||..|:.||:||.|.|||||:|||||.||..||||.|.|:::||||||||||||:|||.||
Zfish   158 VDENFVCFTKHEPIGVCGAIIPWNFPLLMLMWKIAPALACGNTVVLKPAEQTPLTALHVAALIKE 222

  Fly   223 AGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPV 287
            ||||.||:|||.||||||||||:.|.:|.|:|||||.|:|::|..|||:||||||:||||||:|.
Zfish   223 AGFPPGVVNVVPGFGPTAGAAIAGHMNIDKLAFTGSTEVGQLVKAAAASSNLKRVTLELGGKNPC 287

  Fly   288 VVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQ 352
            :||.|:|:..|||.|.:..|.|.||:|.|.||.||.|.:|:|||..:..:||...:|:|.|....
Zfish   288 IVFADSDLQLAVEETQKGAFFNQGQACTAASRVYVQEPVYEEFVRLSVERAKNIVIGDPMEPRTS 352

  Fly   353 QGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQ 417
            .|||||.....|:|..::|||||||||:.||..:.:.|.|:.||:||||||.||||:||||||||
Zfish   353 HGPQIDQHQFEKILALVDSGKKEGAKLEFGGCAVEDRGLFIHPTIFSDVKDHMRIAKEEIFGPVQ 417

  Fly   418 SIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKH 482
            .|.||...:::|||||:.|:||.|.|.|.|:.:|:..:..::||:||:|||:|:...|||||||.
Zfish   418 CIMKFECQQDVIDRANSSQFGLTAAVFTRDVQRAMSVSAALEAGTVWVNCYNALHAQTPFGGYKM 482

  Fly   483 SGIGRELGKDGLDNYLETKTITMKL 507
            ||.|||||:..|..|.|.|.||:||
Zfish   483 SGNGRELGEYALAEYTEVKAITIKL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	266/474 (56%)
aldh1a3	NP_001038210.1	ALDH_F1AB_F2_RALDH1	28..506	CDD:143459	267/477 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830