DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and ALDH8A1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_072090.1	Gene:	ALDH8A1 / 64577	HGNCID:	15471	Length:	487	Species:	Homo sapiens

Alignment Length:	480	Identity:	178/480 - (37%)
Similarity:	272/480 - (56%)	Gaps:	16/480 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNL 101
            ||:.:|:...|  ...:::|:|.:...:|....|.:|:.|||||::||   ..|...||.:|:.:
Human    13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAF---PSWSSRSPQERSRV 72

  Fly   102 MNKLCALMDRDKAFLASLETQDNGKPYAEA-LFDVTYSILTLQYYAGWTDKFFGDTIPAG--GFV 163
            :|::..|:::.....|..|::|.||..|.| ..|:..|:...:::|..:.....:.....  |.:
Human    73 LNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCM 137

  Fly   164 SMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAG 228
            ..|.:.||||.|.|.|||.||.:|.||..||:|.|.|:|.||:|.|.:||..:..|..:||.|.|
Human   138 HYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202

  Fly   229 VINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDA 293
            |:|:|.|.||..|.|:.:||::..::||||......:.|.:| .:.|::|||||||:|.::|:||
Human   203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIFEDA 266

  Fly   294 DIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQID 358
            ::|..:..|..:.|:|.|:.|...||.:|.:.||.||:.:.....:..|||.|.:..|..|..|.
Human   267 NLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALIS 331

  Fly   359 DDMLTKVLGYIESGKKEGAKLQAGG-------KRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPV 416
            ...|.||..|::....|||::..|.       ......|:|:.|||.:|:||:.....|||||||
Human   332 KAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPV 396

  Fly   417 QSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYK 481
            ..:..|.|.||:|:|||||:|||||.|.::::.:..:.|..:.:|.||.||:.....:.||||.|
Human   397 TCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMK 461

  Fly   482 HSGIGRELGKDGLDNYLETKTITMK 506
            .||||||..||..|.:.|.||||:|
Human   462 SSGIGREGAKDSYDFFTEIKTITVK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	177/478 (37%)
ALDH8A1	NP_072090.1	ALDH_F8_HMSADH	27..485	CDD:143412	172/461 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810