DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_071992.2	Gene:	Aldh1l1 / 64392	RGDID:	621294	Length:	902	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	223/516 - (43%)
Similarity:	323/516 - (62%)	Gaps:	24/516 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QLAVSRKWSKFDHTYAQCEPNYC-------------QLFINNEFVDSVSGKTFATFNPATSKEIV 63
            ||.|.:...:.|.  ::|..||.             ||||..||||:...||:.|.||.....|.
  Rat   389 QLLVRKLRGEDDE--SECVINYVEKAVNKLTLQMPYQLFIGGEFVDAEGSKTYNTINPTDGSVIC 451

  Fly    64 QVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPY 128
            |||....:|:|.||.|||:|| .:..|.|::...|..|:.:|..:|::.:..||::|..|.|..|
  Rat   452 QVSLAQVSDVDKAVAAAKEAF-ENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVY 515

  Fly   129 AEAL-FDVTYSILTLQYYAGWTDKFFGDTIPAGGF-----VSMTRKEPVGVVGQIIPWNYPLLML 187
            ..|| ..|..||.|.:|:|||.||..|.|||....     :::|:||||||.|.:|||||||:||
  Rat   516 TLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMML 580

  Fly   188 AWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAK 252
            :||....||.|.|:::|||:.||||||..|.|..:||.|.||:|::.|.|...|..:|.|||:.|
  Rat   581 SWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRK 645

  Fly   253 VAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAG 317
            :.||||.|:|:.:|::.|.||:|:||||||||||:::|.|.|::.||:....::|.|.|::|.|.
  Rat   646 IGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAA 710

  Fly   318 SRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAG 382
            .|.:|.|.|:::||.|...:.:..|:|||.|::...|||..:..|.|::.|.:.|.||||.|..|
  Rat   711 GRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCG 775

  Fly   383 GKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFS--SLEEMIDRANNVQYGLAAGVIT 445
            |.::...|||.:||||:||:|.|.||:||.|||:..|.:|:  .::.::.|||..::|||:||.|
  Rat   776 GNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFT 840

  Fly   446 NDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKHSGIGRELGKDGLDNYLETKTITMK 506
            .||||||..::.:.||:|:||.|:....:.||||:|.||.|::||:..|:.||..||:|.:
  Rat   841 RDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTVTFE 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	217/493 (44%)
Aldh1l1	NP_071992.2	GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		Aldehyde dehydrogenase	417..902		216/486 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750