DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh1a3

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_444310.3	Gene:	Aldh1a3 / 56847	MGIID:	1861722	Length:	512	Species:	Mus musculus

Alignment Length:	480	Identity:	271/480 - (56%)
Similarity:	352/480 - (73%)	Gaps:	2/480 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLS 94
            |..:.::||||::.:|.||:.|||:||:|.::|.:|.||||.|:|.||:||:.||.|.|.||:|.
Mouse    28 EVKFTKIFINNDWHESKSGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLD 92

  Fly    95 PLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEALF-DVTYSILTLQYYAGWTDKFFGDTIP 158
            .|.|..|:::|..|::||:|.||:|||.|.|||:..|.| |:...|.|.:|:|||.||..|.|||
Mouse    93 ALSRGQLLHQLADLVERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWADKIQGRTIP 157

  Fly   159 A-GGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKE 222
            . ...|..||.||:||.|.|.|||:||||||||..|||..|.|:::|||||||||||::|:|.||
Mouse   158 TDDNVVCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLASLIKE 222

  Fly   223 AGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPV 287
            .|||.||:|:|.|||||.|||||:||.|.|:|||||.|:|::|.:||:.||||||:||||||:|.
Mouse   223 VGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVREAASRSNLKRVTLELGGKNPC 287

  Fly   288 VVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQ 352
            :|..|||:|.|||..|:.:|.|.||.|.|.||.:|.|::|.|||.::...||.|.||:||:...:
Mouse   288 IVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRSVEFAKKRPVGDPFDAKTE 352

  Fly   353 QGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQ 417
            ||||||.....|:|..|||||||||||:.||..:.:.|.|::|||||||.|:||||:||||||||
Mouse   353 QGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRGLFIKPTVFSDVTDNMRIAKEEIFGPVQ 417

  Fly   418 SIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKH 482
            .|.||.:|||:|.|||:..|||.|.|.|.:::||||.|..:::|:||||||:|.....||||:|.
Mouse   418 PILKFKNLEEVIKRANSTDYGLTAAVFTKNLDKALKLAAALESGTVWINCYNAFYAQAPFGGFKM 482

  Fly   483 SGIGRELGKDGLDNYLETKTITMKL 507
            ||.|||||:..|..|.|.||:|:||
Mouse   483 SGNGRELGEYALAEYTEVKTVTIKL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	268/474 (57%)
Aldh1a3	NP_444310.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
Aldh1a3	NP_444310.3	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	269/477 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830