DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31075 and aldh5a1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_009290813.1	Gene:	aldh5a1 / 565235	ZFINID:	ZDB-GENE-070228-2	Length:	522	Species:	Danio rerio

Alignment Length:	473	Identity:	184/473 - (38%)
Similarity:	272/473 - (57%)	Gaps:	18/473 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNL 101
            ||:..:|.:.|  :|..|:|||.:||.:||:....:...||.||.|||:.   |:..:..:|:.|
Zfish    52 FIDGRWVSAAS--SFPVFDPATGEEIAKVSDCGTKEAQDAVNAAHKAFNL---WKNHTAKERSIL 111

  Fly   102 MNKLCALMDRDKAFLASLETQDNGKPYAEALFDVTYSILTLQYYAGWTDKFFGDTI--PAGGFVS 164
            :.|...|:.:.:..||.|.|.:.|||..|:|.::|||...|::::....:.:||.:  ||.....
Zfish   112 LRKWFDLIIQHREDLAKLITAECGKPMKESLGEMTYSASFLEWFSEEARRVYGDIVAAPAKDRKI 176

  Fly   165 MTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAGV 229
            :..|:||||...|.|||:|..|:..|.|.|||||||:::||||.|||:||.:|.|:.:||.||||
Zfish   177 LILKQPVGVASIITPWNFPSAMITRKVGAALAVGCTVVVKPAEDTPLSALALAELSVQAGIPAGV 241

  Fly   230 INVV---NGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFD 291
            .|||   ....|..|..:...|.:||::||||...|:::::.|| ..:||||:||||.:|.:|||
Zfish   242 FNVVPCSREKTPAVGELLCTDPLVAKISFTGSTATGKVLLRHAA-GTVKRVSMELGGHAPFIVFD 305

  Fly   292 DADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKAR-KVGNPFEQNVQQGP 355
            .||:|.||.....:.|.|.||:|...:|..|...|:|.||.|.|....|. |:|:..|.:..|||
Zfish   306 SADVDKAVAGAMGSKFRNSGQTCVCSNRFLVQTGIHDAFVEKLAKTMDAELKLGHGSEPSTTQGP 370

  Fly   356 QIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIF 420
            .|:.....||...:......||.:..||||:  .|.|:|||:.|:|..||...:||.|||:..:.
Zfish   371 LINSRAAEKVEKQVADAVDHGAVVVRGGKRL--QGSFMEPTLLSNVTSDMLCMREETFGPLIPVV 433

  Fly   421 KFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPST--PFGGYKHS 483
            ||::.:|.:..||....|||....:.|:.:..:.|..::.|.|.:|  :.::.:|  ||||.|.|
Zfish   434 KFNTEQEALAIANASPVGLAGYFYSRDMAQIWRVAEQMEVGMVGVN--EGMISTTEAPFGGIKQS 496

  Fly   484 GIGRELGKDGLDNYLETK 501
            |:|||....|:|.|||.|
Zfish   497 GLGREGSIYGVDEYLEIK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	184/473 (39%)
aldh5a1	XP_009290813.1	ALDH_F5_SSADH_GabD	66..518	CDD:143421	179/457 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910