DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and aldh16a1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001073423.2	Gene:	aldh16a1 / 492710	ZFINID:	ZDB-GENE-070112-2062	Length:	795	Species:	Danio rerio

Alignment Length:	497	Identity:	132/497 - (26%)
Similarity:	207/497 - (41%)	Gaps:	63/497 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AVSRKW-SKFDHTYAQCEPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSE--GDKADIDL 75
            |.::.| .|...|..        .||:.:|......:|....:   ||..|..|.  ....|:..
Zfish    26 ATAQSWLEKHSRTLG--------FFIDGKFSHPADRQTQDVID---SKAAVVCSTVCAQAEDVAS 79

  Fly    76 AVKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASL--ETQDNGKPYAEALFDVTYS 138
            ||.:|...|   ..|.:||..||..::.||..::.|....::.:  .:|....|        ...
Zfish    80 AVSSAAAGF---KTWSQLSCYQRAKVLLKLPGVLQRHSQCVSEVCELSQSTTSP--------AVL 133

  Fly   139 ILTLQYYAGWTDKFFGDTIPAGGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIM 203
            |...||||.|..  ..||       .|....|.|||..::..:..:..|..|..||||:|..:|:
Zfish   134 IRLAQYYASWAQ--LRDT-------RMPEWSPQGVVTVVVSDDCSVYFLLLKVLPALAMGNAVIV 189

  Fly   204 KPAEQTPLTALHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQA 268
            .|.:.|.|..|.:|.|..|||.||||:||:.|...:..|.::.:|.:..:.|:|..:.|..|.:|
Zfish   190 VPGKTTALPGLLLAQLFMEAGMPAGVLNVLTGSEASLAAKMAQNPQVNYLTFSGCRQTGEAVAKA 254

  Fly   269 AATSNLKRV-SLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTY-----VHEKIY 327
            ||...:... ||......|.::|:.||:|.||:...|..|..        .|.:     |.|.:.
Zfish   255 AAGWGVPMTFSLSSSSVCPFIIFESADLDSAVDGVIELAFKK--------KRDFQWVLCVQESVL 311

  Fly   328 DEFVAKAAAK-AKARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGF 391
            |..||:...: |:.:.|           |...|...:.:...|:..:::||.|..........|.
Zfish   312 DSVVARLKTRMAEMKGV-----------PLASDPDRSIIDAAIQEAQQQGATLIQSCPPASTGGL 365

  Fly   392 FVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFAN 456
            : .|||...:............|||..:..|.|..|.:...|:..:|.||.:.|.|:..||:.|.
Zfish   366 Y-PPTVLCGLAPSCESVISPPPGPVLPLITFRSSAEGVTLGNHSPHGQAASIWTEDLTLALESAK 429

  Fly   457 NVDAGSVWINCYDAVLPSTPFGGYKHSGIGRELGKDGLDNYL 498
            ::..||||:||:..:.|:.|..|.:.||...:.|::||..:|
Zfish   430 SLCVGSVWVNCHSVMDPALPLCGRRDSGNCTDGGREGLYQFL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	128/477 (27%)
aldh16a1	NP_001073423.2	ALDH-SF	18..470	CDD:299846	131/494 (27%)
aldh16a1	NP_001073423.2	AdhE	514..>755	CDD:223944
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740