DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31075 and aldh8a1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001004540.1	Gene:	aldh8a1 / 447801	ZFINID:	ZDB-GENE-040912-3	Length:	487	Species:	Danio rerio

Alignment Length:	482	Identity:	185/482 - (38%)
Similarity:	273/482 - (56%)	Gaps:	20/482 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNL 101
            :|..:||.  ..|...:|:|:|.:...:|.:....:::.||:|||:||   .:|...||..|:.:
Zfish    13 YIGGKFVP--CSKLIDSFDPSTGEVYCKVPDSGAEEVNAAVRAAKEAF---PDWSAKSPADRSKV 72

  Fly   102 MNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSILTLQYYAGWTDKFFGD--TIPAGGFV 163
            :|||..|::.........|::|.||....|. .|:..|....:::|........|  .:...|.:
Zfish    73 LNKLADLIEARLEEFVQAESKDQGKTITFARNVDIPRSAYNFRFFASSVLHHTNDCSQMDHMGCL 137

  Fly   164 SMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAG 228
            :.|.:.||||.|.|.|||.||.:|.||..||:|.|.|::.||:|.|.:||..|..|.:|||||.|
Zfish   138 NYTIRCPVGVAGLISPWNLPLYLLTWKIAPAVATGNTVVAKPSEMTSVTAWMMCQLLEEAGFPPG 202

  Fly   229 VINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDA 293
            |:|:|.|.||.||.|:.:|||:..::||||....|::.:.:| .:.|::|||||||:|.::|.||
Zfish   203 VVNIVFGTGPRAGDALVSHPDVPLISFTGSTATARLITERSA-PHCKKLSLELGGKNPAIIFADA 266

  Fly   294 DIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQID 358
            |::..:.||..:.|||.|:.|...||.:|...:|.||:.:.....:..|.|.|.:.:...|..|.
Zfish   267 DMEQCISTTVRSSFSNQGEICLCTSRIFVERSVYPEFLTRFVEATRRWKTGVPSDPSNDNGALIS 331

  Fly   359 DDMLTKVLGYIESGKKEGAKLQAG---------GKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFG 414
            .:.|.||.|||.....|||::..|         .:.||  |:|:.||:.|.|||...:.||||||
Zfish   332 KEHLQKVKGYITLALAEGAQVHCGEGVDKLALPQQNIG--GYFMLPTIISGVKDSSALMQEEIFG 394

  Fly   415 PVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGG 479
            ||..:..|...||:|.|||||:|||:|.|.:.|:.:..:.|..:.||.||.||:.....:.||||
Zfish   395 PVTCVTPFDEEEEVISRANNVRYGLSATVWSRDVGRVHRVARKLQAGLVWTNCWLVRDLNLPFGG 459

  Fly   480 YKHSGIGRELGKDGLDNYLETKTITMK 506
            .||||||||.|||....:.|.|::|:|
Zfish   460 MKHSGIGREGGKDSYHFFTEVKSVTVK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	184/480 (38%)
aldh8a1	NP_001004540.1	ALDH_F8_HMSADH	27..485	CDD:143412	179/463 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810