DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and CG8665

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_610107.1	Gene:	CG8665 / 35407	FlyBaseID:	FBgn0032945	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	217/481 - (45%)
Similarity:	311/481 - (64%)	Gaps:	11/481 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRT 99
            |||||.||||:.:.:|....||...:.:.:|:.....|:|.||:||..||:  ..||:::|.||.
  Fly   434 QLFINGEFVDAEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHSAFY--GSWRQITPRQRG 496

  Fly   100 NLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSILTLQYYAGWTDKFFGDTIPA---- 159
            .||..|..||:|:|..||::|:.|:|..|..|| ..|..||...:|:|||.||..|:|||.
  Fly   497 QLMLNLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVNPAR 561

  Fly   160 -GGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEA 223
             ...::.|||||:||.|.|.||||||:||:||....:|.|.|.::|||:..|||||..|.|...|
  Fly   562 PNNVLTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELTVRA 626

  Fly   224 GFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVV 288
            |||.|||||:.|.|..||.|::.|..:.|:.||||..||:.:|::.|.||||:.|||||||||::
  Fly   627 GFPPGVINVLPGKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPLI 691

  Fly   289 VFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQ 353
            :|.|.|:|.||:....::|.|.|::|.|..|.:|.::|:|||:.:.....:...:|:|.:::...
  Fly   692 IFADCDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPLDRSTAH 756

  Fly   354 GPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNV-GFFVEPTVFSDVKDDMRIAQEEIFGPVQ 417
            |||.......|:|.:...|..|||||..||.|:.|: |:|..||||::|.|||.|||||.|||:.
  Fly   757 GPQNHKAHFDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESFGPIM 821

  Fly   418 SIFKF--SSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGY 480
            .|.||  |.::.::.|||..:||||:||.|.||.|||.||:.::||:|::|.|:....:.||||:
  Fly   822 IISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTVFVNVYNKTDVAAPFGGF 886

  Fly   481 KHSGIGRELGKDGLDNYLETKTITMK 506
            |.||.|::||::.|:.||:||.:|::
  Fly   887 KQSGYGKDLGQEALNEYLKTKCVTVE 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	217/479 (45%)
CG8665	NP_610107.1	Fmt	4..315	CDD:223301
		FMT_core	5..207	CDD:294280
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	338..403	CDD:278949
		PLN02466	396..909	CDD:215259	216/476 (45%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	217/481 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454125
Domainoid	1	1.000	389	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I51
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51311
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900