DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001178707.2	Gene:	Aldh1l2 / 299699	RGDID:	1309458	Length:	923	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	219/486 - (45%)
Similarity:	314/486 - (64%)	Gaps:	21/486 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRT 99
            |.|||.:|||:..|:|:||.||.....:.:||....||:|.||.|||.|| .:.||.:::...|.
  Rat   444 QCFINGQFVDAEDGETYATINPTDGTTLCRVSYASLADVDRAVAAAKDAF-ENGEWGRMNARDRG 507

  Fly   100 NLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSILTLQYYAGWTDKF----------- 152
            .||.:|..||:.::..||::|..|:|..|..|| ..:..|:.|.:|:|||.||.
  Rat   508 RLMYRLADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQVTKEPENQAR 572

  Fly   153 FGDTIPAGGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMA 217
            ..||:      .|:.:||..|...||||||||:|||||....||.|.|:::|||:.||||||..|
  Rat   573 IHDTL------GMSSEEPKVVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFA 631

  Fly   218 ALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELG 282
            .|..:||||.||||::.|.|..||..:|.||||.|:.||||..:|:.:|::.|.||||:||||||
  Rat   632 ELTVKAGFPKGVINIIPGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCAVSNLKKVSLELG 696

  Fly   283 GKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPF 347
            ||||:::|.|.::|.||.....|:|.|.|::|.|..|.:|.|.|:||||.:...:.|..|:|:|.
  Rat   697 GKSPLIIFSDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPL 761

  Fly   348 EQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEI 412
            :::...|||.....|.|:|.|.|:|.||||.|..||:::...|||:|||||:.|:|.|.:|:||.
  Rat   762 DRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEES 826

  Fly   413 FGPVQSIFKFSS--LEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPST 475
            |||:..|.||.:  ::.::.||||.:||||:||.|.||:||:..::.::||:|:||.|:....:.
  Rat   827 FGPIMVISKFQNGDIDGVLQRANNTEYGLASGVFTRDISKAMYVSDRLEAGTVFINTYNKTDVAA 891

  Fly   476 PFGGYKHSGIGRELGKDGLDNYLETKTITMK 506
            ||||.|.||.|::||::.|:.||:|||:|::
  Rat   892 PFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	219/484 (45%)
Aldh1l2	NP_001178707.2	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:395435
		ALDH_F1L_FTFDH	438..923	CDD:143458	219/486 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750