DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh2

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_115792.2	Gene:	Aldh2 / 29539	RGDID:	69219	Length:	519	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	288/514 - (56%)
Similarity:	369/514 - (71%)	Gaps:	14/514 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLAHQLAVSRKWSKFDH------TYAQCEPN-----YC-QLFINNEFVDSVSGKTFATFNPATSK 60
            :|...|:.:|:..:...      |.|...||     :| |:|||||:.|:||.|||.|.||:|.:
  Rat     1 MLRAALSTARRGPRLSRLLSAAATSAVPAPNQQPEVFCNQIFINNEWHDAVSKKTFPTVNPSTGE 65

  Fly    61 EIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNG 125
            .|.||:||:|.|:|.|||||:.||...|.||::....|..|:.:|..|::||:.:||:|||.|||
  Rat    66 VICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNG 130

  Fly   126 KPYA-EALFDVTYSILTLQYYAGWTDKFFGDTIPA-GGFVSMTRKEPVGVVGQIIPWNYPLLMLA 188
            |||. ..|.|:...:..|:|||||.||:.|.|||. |.|.|.||.|||||.|||||||:||||.|
  Rat   131 KPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQA 195

  Fly   189 WKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKV 253
            ||.|||||.|..::||.|||||||||::|.|.||||||.||:|:|.||||||||||::|.|:.||
  Rat   196 WKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKV 260

  Fly   254 AFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGS 318
            |||||.|:|.::..||.:||||||:||||||||.::..|||:|:|||..|.|||.|.||.|||||
  Rat   261 AFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGS 325

  Fly   319 RTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGG 383
            ||:|.|.:|||||.::.|:||:|.|||||:...:||||:|:....|:||||:||::|||||..||
  Rat   326 RTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGG 390

  Fly   384 KRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDI 448
            ....:.|:|::||||.||||.|.||:|||||||..|.||.::||::.||||.:|||||.|.|.|:
  Rat   391 GAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAVFTKDL 455

  Fly   449 NKALKFANNVDAGSVWINCYDAVLPSTPFGGYKHSGIGRELGKDGLDNYLETKTITMKL 507
            :||...:..:.||:|||||||.....:||||||.||.|||||:.||..|.|.||:|:|:
  Rat   456 DKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKV 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	280/475 (59%)
Aldh2	NP_115792.2	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	280/479 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830