DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh7a1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001258034.1	Gene:	Aldh7a1 / 291450	RGDID:	1308614	Length:	539	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	146/530 - (27%)
Similarity:	252/530 - (47%)	Gaps:	44/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQKLLAHQLAVSRKWSK---FDHTYAQCEPNYC-----QLFINNEFVDSVS----GKTFATFNPA 57
            :|.:.|.:|  ||.||:   ...|.....|.|.     .|..:||.|.:.|    |:...|:.||
  Rat    10 VQTVKASKL--SRLWSRPAALMSTLLIHHPQYAWLQDLGLREDNEGVFNGSWGGRGEVITTYCPA 72

  Fly    58 TSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQ 122
            .::.|.:|.:....|.:..:..||||:   :.|..:...:|..::.|:...:......|..|.:.
  Rat    73 NNEPIARVRQASMKDYEETIGKAKKAW---NIWADIPAPKRGEIVRKIGDALREKIQLLGRLVSL 134

  Fly   123 DNGKPYAEALFDVTYSILTLQYYAGWTDKFFGDTIPA--GGFVSMTRKEPVGVVGQIIPWNYPLL 185
            :.||...|.:.:|...:....|.||.:....|.|:|:  .|...|.:..|:|:||.|..:|:|:.
  Rat   135 EMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALMEQWNPLGLVGIITAFNFPVA 199

  Fly   186 MLAWKWGPALAVGCTIIMKPAEQTPLTALH----MAALAKEAGFPAGVINVVNGFGPTAGAAISA 246
            :..|....||..|...:.|.|..|.|.::.    :|.:.::...|..:.::..| |...|.|::.
  Rat   200 VFGWNNAIALITGNVCLWKGAPTTSLVSIAVTKIIAKVLEDNLLPGAICSLTCG-GADMGTAMAR 263

  Fly   247 HPDIAKVAFTGSVEIGR---IVMQAAATSNLKRVSLELGGKSPVVVFDDADIDFAVETTHEALFS 308
            ...:..::||||.::|:   :::|.....:|    |||||.:.::.|:|||:...:.:...|...
  Rat   264 DERVNLLSFTGSTQVGKQVALMVQERFGKSL----LELGGNNAIIAFEDADLSLVLPSALFAAVG 324

  Fly   309 NHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGK 373
            ..||.|....|.::||.|:||.|.:........:||||::.|:..||......::..:..:|..|
  Rat   325 TAGQRCTTVRRLFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAK 389

  Fly   374 KEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSSLEEMIDRANNVQYG 438
            |||..:..|||.:.:.|.:||||:.:.:..|..|..:|.|.|:..:|||.:.||:.:..|.|:.|
  Rat   390 KEGGTVVYGGKVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNEVKQG 454

  Fly   439 LAAGVITNDINKALKF--ANNVDAGSVWINCYDAVLPST------PFGGYKHSGIGRELGKDGLD 495
            |::.:.|.|:.:..::  ....|.|.|.:|     :|::      .|||.||:|.|||.|.|...
  Rat   455 LSSSIFTKDLGRIFRWLGPKGSDCGIVNVN-----IPTSGAEIGGAFGGEKHTGGGRESGSDAWK 514

  Fly   496 NYLETKTITM 505
            .|:...|.|:
  Rat   515 QYMRRSTCTI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	137/499 (27%)
Aldh7a1	NP_001258034.1	ALDH_F7_AASADH	53..527	CDD:143448	133/485 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810