DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh1a7

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_036051.1	Gene:	Aldh1a7 / 26358	MGIID:	1347050	Length:	501	Species:	Mus musculus

Alignment Length:	489	Identity:	281/489 - (57%)
Similarity:	355/489 - (72%)	Gaps:	11/489 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KFDHTYAQCEPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFH 85
            |..||         ::|||||:.||||.|.|...||||.:.|..|.||||||:|.|||||::||.
Mouse    17 KIQHT---------KIFINNEWHDSVSSKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQ 72

  Fly    86 RDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEA-LFDVTYSILTLQYYAGWT 149
            ..|.||.:...:|..|:|||..||:||:..||::|:.:.||.:|.| |.||..||..|||:|||.
Mouse    73 IGSPWRTMDASERGRLLNKLADLMERDRLLLATMESMNAGKVFAHAYLLDVEISIKALQYFAGWA 137

  Fly   150 DKFFGDTIPA-GGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTA 213
            ||..|.|||: |...:.||:||:||.|||||||.||::..||.||||:.|.|:::||||||||||
Mouse   138 DKIHGQTIPSDGNIFTYTRREPIGVCGQIIPWNGPLIIFTWKLGPALSCGNTVVVKPAEQTPLTA 202

  Fly   214 LHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVS 278
            ||||:|.||||||.||:|:|.|:|||||.|||:|.||.||:||||.|:|:::.:||..||||||:
Mouse   203 LHMASLIKEAGFPPGVVNIVPGYGPTAGGAISSHMDIDKVSFTGSTEVGKLIKEAAGKSNLKRVT 267

  Fly   279 LELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKV 343
            ||||||||.:||.|||:|.|||..|:.:|.:.||.|.|.||.:|.|.||||||.::..:||...:
Mouse   268 LELGGKSPCIVFADADLDSAVEFAHQGVFFHQGQICVAASRLFVEESIYDEFVRRSVERAKKYIL 332

  Fly   344 GNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIA 408
            |||....:.||||||.:...|:||.|||||||||||:.||.|.||.||||:|||||:|.|:||||
Mouse   333 GNPLNSGINQGPQIDKEQHNKILGLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIA 397

  Fly   409 QEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLP 473
            :||||||||.|.||.|::::|.||||..|||||||.|.|::||:..::.:.||.||:|||.||..
Mouse   398 KEEIFGPVQQIMKFKSMDDVIKRANNTTYGLAAGVFTKDLDKAITVSSALQAGMVWVNCYLAVPV 462

  Fly   474 STPFGGYKHSGIGRELGKDGLDNYLETKTITMKL 507
            ..||||:|.||.|||||:.||..|.|.||:.|::
Mouse   463 QCPFGGFKMSGNGRELGEHGLYEYTELKTVAMQI 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	277/474 (58%)
Aldh1a7	NP_036051.1	ALDH_F1AB_F2_RALDH1	15..494	CDD:143459	280/485 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H137245
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760