DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh1a1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_038949786.1	Gene:	Aldh1a1 / 24188	RGDID:	2087	Length:	520	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	280/489 - (57%)
Similarity:	355/489 - (72%)	Gaps:	11/489 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KFDHTYAQCEPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFH 85
            |..||         ::|||||:.||||||.|...||||.:.|..|.||||||:|.|||||::||.
  Rat    36 KIQHT---------KIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQ 91

  Fly    86 RDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEA-LFDVTYSILTLQYYAGWT 149
            ..|.||.:...:|..|:|||..||:||:..||::|..:.||.:|.| |.|:..||..|:|.|||.
  Rat    92 IGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWA 156

  Fly   150 DKFFGDTIPAGGFV-SMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTA 213
            ||..|.|||:.|.: :.||:||:||.|||||||:||||..||.||||:.|.|:::||||||||||
  Rat   157 DKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTA 221

  Fly   214 LHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVS 278
            ||||:|.||||||.||:|:|.|:|||||||||:|.|:.|||||||.::|:::.:||..||||||:
  Rat   222 LHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVT 286

  Fly   279 LELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKV 343
            ||||||||.:||.|||:|.|||..|..:|.:.||.|.|.||.:|.|.:|||||.|:..:||...:
  Rat   287 LELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVL 351

  Fly   344 GNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIA 408
            |||..|.:.||||||.:...|:|..|||||||||||:.||.|.||.||||:|||||:|.|:||||
  Rat   352 GNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIA 416

  Fly   409 QEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLP 473
            :||||||||.|.||.|::::|.||||..|||||||.|.|:::|:..::.:.||.||:|||..:..
  Rat   417 KEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSA 481

  Fly   474 STPFGGYKHSGIGRELGKDGLDNYLETKTITMKL 507
            ..||||:|.||.|||||:.||..|.|.||:.||:
  Rat   482 QCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	275/474 (58%)
Aldh1a1	XP_038949786.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	278/486 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760