DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh8a1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_848828.1	Gene:	Aldh8a1 / 237320	MGIID:	2653900	Length:	487	Species:	Mus musculus

Alignment Length:	477	Identity:	177/477 - (37%)
Similarity:	268/477 - (56%)	Gaps:	22/477 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNLMNK 104
            |.::||        ::|:|.:...:|....|.:|:.||:||::||   ..|...||.:|:.::|:
Mouse    22 NSYIDS--------YDPSTGEVYCKVPNSGKEEIEAAVEAAREAF---PAWSSRSPQERSLVLNR 75

  Fly   105 LCALMDRDKAFLASLETQDNGKPYAEA-LFDVTYSILTLQYYAGWTDKFFGDTIPAG--GFVSMT 166
            |..::::....||..|::|.||....| ..|:..|:|..:::|........:.....  |.:..|
Mouse    76 LADVLEQSLEELAQAESKDQGKTLTLARTMDIPRSVLNFRFFASSNLHHVSECTQMSHLGCMHYT 140

  Fly   167 RKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAGVIN 231
            .:.|||:.|.|.|||.||.:|.||..||:|.|.|:|.||:|.|.:||.....|..:||.|.||||
Mouse   141 VRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSEMTSVTAWMFCKLLDKAGVPPGVIN 205

  Fly   232 VVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDADID 296
            :|.|.||..|.|:.:||::..::||||......:.|.:| .:.|::|||||||:|.::|:||:::
Mouse   206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIFEDANLE 269

  Fly   297 FAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQIDDDM 361
            ..:..|..:.|:|.|:.|...||.:|...||.||:.:.....:..|||.|.:.:...|..|....
Mouse   270 ECIPATVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEATRKWKVGVPSDPSANMGALISKAH 334

  Fly   362 LTKVLGYIESGKKEGAKLQAG------GKRIGN-VGFFVEPTVFSDVKDDMRIAQEEIFGPVQSI 419
            |.||..|:...:.|||::..|      ...:.| .|:|:.|||.:|:||:.|...|||||||..:
Mouse   335 LEKVRSYVLKAQTEGARILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESRCMTEEIFGPVTCV 399

  Fly   420 FKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKHSG 484
            ..|.|.||:|.|||:|:|||||.|.:.|:.:..:.|..:.:|.||.||:.....:.||||.|.||
Mouse   400 VPFDSEEEVITRANSVRYGLAATVWSKDVGRIHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSG 464

  Fly   485 IGRELGKDGLDNYLETKTITMK 506
            ||||..||..|.:.|.||||:|
Mouse   465 IGREGAKDSYDFFTEIKTITIK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	176/475 (37%)
Aldh8a1	NP_848828.1	ALDH_F8_HMSADH	27..485	CDD:143412	173/469 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810