DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and Aldh1a2

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_033048.2	Gene:	Aldh1a2 / 19378	MGIID:	107928	Length:	518	Species:	Mus musculus

Alignment Length:	480	Identity:	268/480 - (55%)
Similarity:	358/480 - (74%)	Gaps:	2/480 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLS 94
            |..|.::|||||:.:|.||:.|...||||.:::.:|.|.||.|||.||:||:.||...|.||::.
Mouse    34 EIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMD 98

  Fly    95 PLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEALF-DVTYSILTLQYYAGWTDKFFGDTIP 158
            ..:|..|::||..|::||:|.||::|:.:.|||:.:|.: |:...|.||:|||||.||..|.|||
Mouse    99 ASERGRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGMTIP 163

  Fly   159 A-GGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKE 222
            . |.:.:.||.||:||.|||||||:||||..||..|||..|.|:::||||||||:||:|.||.||
Mouse   164 VDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE 228

  Fly   223 AGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPV 287
            ||||.||:|::.|:||||||||::|..|.|:|||||.|:|:::.:||..||||||:||||||||.
Mouse   229 AGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPN 293

  Fly   288 VVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQ 352
            ::|.|||:|:|||..|:.:|.|.||.|.||||.:|.|.||:|||.::..:||.|.||:||:...:
Mouse   294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTE 358

  Fly   353 QGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQ 417
            ||||||.....|||..|:||..|||||:.|||.:|..|||:||||||:|.||||||:||||||||
Mouse   359 QGPQIDKKQYNKVLELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQ 423

  Fly   418 SIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKH 482
            .|.:|.:::|:|:||||..:||.|.|.||||||||..::.:.||:||||||:|:...:||||:|.
Mouse   424 EILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKM 488

  Fly   483 SGIGRELGKDGLDNYLETKTITMKL 507
            ||.|||:|:.||..|.|.||:|:|:
Mouse   489 SGNGREMGEFGLREYSEVKTVTVKI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	266/474 (56%)
Aldh1a2	NP_033048.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	267/477 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760