DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and ALDH16A1

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_699160.2	Gene:	ALDH16A1 / 126133	HGNCID:	28114	Length:	802	Species:	Homo sapiens

Alignment Length:	511	Identity:	144/511 - (28%)
Similarity:	231/511 - (45%)	Gaps:	82/511 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLLAHQLAVSRKWSKFDHTYAQCEPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKA 71
            :.|.|.  |:.||.|.:|  ....|  ||                   :|.|.:.:....:....
Human    38 RCLGHY--VNGKWLKPEH--RNSVP--CQ-------------------DPITGENLASCLQAQAE 77

  Fly    72 DIDLAVKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDV 135
            |:..||:||:.||   ..|.....:.|...:.:|..::.:.:..|.:||:...|:...|.. .||
Human    78 DVAAAVEAARMAF---KGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDV 139

  Fly   136 TYSILTLQYY-----------AGWTDKFFGDTIPAGGFVSMTRKEPVGVVGQIIPWNYPLLMLAW 189
            ..:...|.|:           |||                    ||:||:|.|:|..:..|.:.|
Human   140 QLAQQLLHYHAIQASTQEEALAGW--------------------EPMGVIGLILPPTFSFLEMMW 184

  Fly   190 KWGPALAVGCTII--MKPAEQTPLTALHMAALAKEAG-FPAGVINVVNGFGPTAGAAI-SAHPDI 250
            :..||||||||::  :.||...||.   :|.||.|.| || |::||::  ||.:...| ::.|.|
Human   185 RICPALAVGCTVVALVPPASPAPLL---LAQLAGELGPFP-GILNVLS--GPASLVPILASQPGI 243

  Fly   251 AKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCC 315
            .||||.|:.|.||.:.::.| .....:.|.||.:|.:::.|.||:|.|||...:|.:|:.|.
Human   244 RKVAFCGAPEEGRALRRSLA-GECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP--- 304

  Fly   316 AGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQ--IDDDMLTKVLGYIESGKKEGAK 378
            .|.|..:.|.::||.:.:...:....:.|...:..|..|.:  ...|::.:   ::...:.:||:
Human   305 GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQR---FVREAQSQGAQ 366

  Fly   379 L-QAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAG 442
            : |||.  :.:...|..||:.|::......||.|:..||.....|.:.:|.:..||....|.:|.
Human   367 VFQAGD--VPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSAS 429

  Fly   443 VITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYKHSGIGRELGKDGLDNYL 498
            |.:..:.:||:....:..|:||||.:....||.|.||.|.||.....|.|||..||
Human   430 VWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	136/485 (28%)
ALDH16A1	NP_699160.2	ALDH-SF	19..492	CDD:299846	144/511 (28%)
ALDH16A1	NP_699160.2	ALDH-SF	527..>765	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740