DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and aldh1l2

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_002661418.2	Gene:	aldh1l2 / 100333269	ZFINID:	ZDB-GENE-100426-6	Length:	923	Species:	Danio rerio

Alignment Length:	495	Identity:	225/495 - (45%)
Similarity:	316/495 - (63%)	Gaps:	15/495 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YAQCEPNYC------QLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAF 84
            ||..|.|..      |.|||.:|.|:..|||:.|.||.....|.:||....||:|.||.|||:||
Zfish   429 YATKEVNNMTVKMPYQCFINGKFEDADDGKTYNTVNPTDGSVICKVSYASVADVDKAVSAAKEAF 493

  Fly    85 HRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSILTLQYYAGW 148
            . :..|.|::|..|..|:.:|..||:..:..||::||.|:|..|..|| ..|..||.|.:|:|||
Zfish   494 D-NGPWGKMNPRDRGQLLYRLADLMEEHQEELATIETIDSGAVYTLALKTHVGMSIQTFRYFAGW 557

  Fly   149 TDKFFGDTIPAGGF-----VSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQ 208
            .||..|.|||....     ::.|:|||:||...:|||||||:|||||....||.|.|:::|||:.
Zfish   558 CDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIVIPWNYPLMMLAWKSAACLAAGNTLVLKPAQV 622

  Fly   209 TPLTALHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSN 273
            ||||||..|.|..:||.|.||||:|.|.|...|..:|.||||.|:.||||..||:.:|::.|.||
Zfish   623 TPLTALKFAELTIKAGIPKGVINIVPGSGGLVGQRMSEHPDIRKLGFTGSTPIGKQIMKSCAVSN 687

  Fly   274 LKRVSLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKA 338
            ||:||||||||||:::|.|.|:|.||.....:::.|.|::|.|..|.:|.|.|:||::.:...:.
Zfish   688 LKKVSLELGGKSPLIIFSDCDMDKAVRMGMSSVYFNKGENCIAAGRLFVEESIHDEYIRRVVEEI 752

  Fly   339 KARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKD 403
            |..|:|:|.:::...|||.....:.|::.|.|.|.||||.|..||:::...|||:|||||:||:|
Zfish   753 KKMKIGDPLDRSTDHGPQNHKAHMDKLVEYCEIGVKEGATLVYGGRQVDRPGFFMEPTVFTDVED 817

  Fly   404 DMRIAQEEIFGPVQSIFKF--SSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWIN 466
            .|.||:||.||||..:.||  ..::.::.|||:.::|||:||.|.|||||:..:..::||:|:||
Zfish   818 HMFIAKEESFGPVMVVSKFKDGDVDGVLSRANDTEFGLASGVFTRDINKAMYVSERLEAGTVFIN 882

  Fly   467 CYDAVLPSTPFGGYKHSGIGRELGKDGLDNYLETKTITMK 506
            .|:....:.||||:|.||.|::||:|.|..||.||.:|::
Zfish   883 TYNKTDVAAPFGGFKQSGFGKDLGEDALHEYLRTKAVTVE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	221/486 (45%)
aldh1l2	XP_002661418.2	Fmt	22..323	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..412	CDD:278949
		ALDH_F1L_FTFDH	438..923	CDD:143458	221/486 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750