DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31075 and aldh1l2

DIOPT Version :9

Sequence 1:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_002938116.1	Gene:	aldh1l2 / 100127737	XenbaseID:	XB-GENE-5820495	Length:	922	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	221/480 - (46%)
Similarity:	313/480 - (65%)	Gaps:	9/480 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRT 99
            |.|||.:|.|:.:|||:.|.||.....|.:|:....||:|.||.|||.|| .:.||.|::...|.
Frog   443 QCFINGQFADADNGKTYDTINPTDGSVICKVAYCSVADVDKAVAAAKDAF-ENGEWGKMNARDRG 506

  Fly   100 NLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSILTLQYYAGWTDKFFGDTIPAGGF- 162
            .::.:|..||:..:..||::|..|:|..|..|| ..|..|:.|.:|:|||.||..|.|||....
Frog   507 RILYRLADLMEEHQEELATIEAIDSGAVYTLALKTHVGMSVQTFRYFAGWCDKIQGSTIPINQAR 571

  Fly   163 ----VSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAALAKEA 223
                ::.|:|||:||...:|||||||:|||||....||.|.|:::|||:.||||||..|.||.:|
Frog   572 PNRNLTFTKKEPLGVCAIVIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELAVKA 636

  Fly   224 GFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGGKSPVV 288
            |.|.||||::.|.|...|..:|.||||.|:.||||..||:.:|::.|.||||:||||||||||::
Frog   637 GVPKGVINILPGSGGLVGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLI 701

  Fly   289 VFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQ 353
            :|:|.|:|.||.....|::.|.|::|.|..|.:|.|.|:||||.:...:.|..::|:|.:::...
Frog   702 IFNDCDLDKAVRMGMGAVYFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMRIGDPLDRSTDH 766

  Fly   354 GPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQS 418
            |||.....|.|:|.|.|.|.||||.|..||:::...|||:|||||:||:|.|.:|:||.|||:..
Frog   767 GPQNHRAHLEKLLEYCEIGVKEGATLVYGGRKVPRPGFFMEPTVFTDVEDHMYLAEEESFGPIMV 831

  Fly   419 IFKF--SSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPFGGYK 481
            |.||  ..::.::.||||.:||||:||.|.||:||:..:..:|||:|:||.|:....:.||||:|
Frog   832 ISKFKDGDIDGVLRRANNTEYGLASGVFTKDISKAMYVSEKLDAGTVFINTYNKTDVAAPFGGFK 896

  Fly   482 HSGIGRELGKDGLDNYLETKTITMK 506
            .||.|::||::.|..||.||.:|::
Frog   897 QSGFGKDLGEEALHEYLRTKAVTVE 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	221/478 (46%)
aldh1l2	XP_002938116.1	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..412	CDD:376348
		ALDH_F1L_FTFDH	437..922	CDD:143458	221/480 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010